De Clercq E - Search Results

1

2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.

Balzarinia J, Degrève B, Zhu C, Durini E, Porcu L, De Clercq E, Karlsson A, Manfredini S. Balzarinia J, et al. Among authors: de clercq e. Biochem Pharmacol. 2001 Mar 15;61(6):727-32. doi: 10.1016/s0006-2952(01)00529-9. Biochem Pharmacol. 2001. PMID: 11266658

2

The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides.

Balzarini J, Degrève B, Hatse S, De Clercq E, Breuer M, Johansson M, Huybrechts R, Karlsson A. Balzarini J, et al. Among authors: de clercq e. Mol Pharmacol. 2000 Apr;57(4):811-9. doi: 10.1124/mol.57.4.811. Mol Pharmacol. 2000. PMID: 10727530

3

Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2.

Balzarini J, Zhu C, De Clercq E, Pérez-Pérez MJ, Chamorro C, Camarasa MJ, Karlsson A. Balzarini J, et al. Among authors: de clercq e. Biochem J. 2000 Oct 1;351(Pt 1):167-71. doi: 10.1042/0264-6021:3510167. Biochem J. 2000. PMID: 10998359 Free PMC article.

4

Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.

Degrève B, Esnouf R, De Clercq E, Balzarini J. Degrève B, et al. Among authors: de clercq e. Mol Pharmacol. 2000 Dec;58(6):1326-32. doi: 10.1124/mol.58.6.1326. Mol Pharmacol. 2000. PMID: 11093770

5

Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.

Degrève B, Esnouf R, De Clercq E, Balzarini J. Degrève B, et al. Among authors: de clercq e. Mol Pharmacol. 2001 Feb;59(2):285-93. doi: 10.1124/mol.59.2.285. Mol Pharmacol. 2001. PMID: 11160865

6

Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors.

Balzarini J, Kleim JP, Riess G, Camarasa MJ, De Clercq E, Karlsson A. Balzarini J, et al. Among authors: de clercq e. Biochem Biophys Res Commun. 1994 Jun 30;201(3):1305-12. doi: 10.1006/bbrc.1994.1846. Biochem Biophys Res Commun. 1994. PMID: 7517668

7

Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues.

Balzarini J, Velazquez S, San-Felix A, Karlsson A, Perez-Perez MJ, Camarasa MJ, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Mol Pharmacol. 1993 Jan;43(1):109-14. Mol Pharmacol. 1993. PMID: 7678689

8

Human immunodeficiency virus type 1 drug-resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.

Balzarini J, Karlsson A, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Mol Pharmacol. 1993 Oct;44(4):694-701. Mol Pharmacol. 1993. PMID: 7694068

9

Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.

Degrève B, Andrei G, Izquierdo M, Piette J, Morin K, Knaus EE, Wiebe LI, Basrah I, Walker RT, De Clercq E, Balzarini J. Degrève B, et al. Among authors: de clercq e. Gene Ther. 1997 Oct;4(10):1107-14. doi: 10.1038/sj.gt.3300502. Gene Ther. 1997. PMID: 9415318

10

Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication.

Neyts J, Balzarini J, Andrei G, Chaoyong Z, Snoeck R, Zimmermann A, Mertens T, Karlsson A, De Clercq E. Neyts J, et al. Among authors: de clercq e. Mol Pharmacol. 1998 Jan;53(1):157-65. doi: 10.1124/mol.53.1.157. Mol Pharmacol. 1998. PMID: 9443944

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