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Mobilization of innate and adaptive antitumor immune responses by the RNP-targeting antibody ATRC-101.
Scholz A, DeFalco J, Leung Y, Aydin IT, Czupalla CJ, Cao W, Santos D, Vad N, Lippow SM, Baia G, Harbell M, Sapugay J, Zhang D, Wu DC, Wechsler E, Ye AZ, Wu JW, Peng X, Vivian J, Kaplan H, Collins R, Nguyen N, Whidden M, Kim D, Millward C, Benjamin J, Greenberg NM, Serafini TA, Emerling DE, Steinman L, Robinson WH, Manning-Bog A. Scholz A, et al. Among authors: defalco j. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2123483119. doi: 10.1073/pnas.2123483119. Epub 2022 May 4. Proc Natl Acad Sci U S A. 2022. PMID: 35507878 Free PMC article.
Non-progressing cancer patients have persistent B cell responses expressing shared antibody paratopes that target public tumor antigens.
DeFalco J, Harbell M, Manning-Bog A, Baia G, Scholz A, Millare B, Sumi M, Zhang D, Chu F, Dowd C, Zuno-Mitchell P, Kim D, Leung Y, Jiang S, Tang X, Williamson KS, Chen X, Carroll SM, Espiritu Santo G, Haaser N, Nguyen N, Giladi E, Minor D, Tan YC, Sokolove JB, Steinman L, Serafini TA, Cavet G, Greenberg NM, Glanville J, Volkmuth W, Emerling DE, Robinson WH. DeFalco J, et al. Clin Immunol. 2018 Feb;187:37-45. doi: 10.1016/j.clim.2017.10.002. Epub 2017 Oct 12. Clin Immunol. 2018. PMID: 29031828 Free article.
TRPM8 biology and medicinal chemistry.
DeFalco J, Duncton MA, Emerling D. DeFalco J, et al. Curr Top Med Chem. 2011;11(17):2237-52. doi: 10.2174/156802611796904933. Curr Top Med Chem. 2011. PMID: 21671871 Review.
15 results