Loeb LA - Search Results

1

Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells.

Davis BM, Encell LP, Zielske SP, Christians FC, Liu L, Friebert SE, Loeb LA, Gerson SL. Davis BM, et al. Among authors: loeb la. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4950-4. doi: 10.1073/pnas.091601198. Epub 2001 Apr 10. Proc Natl Acad Sci U S A. 2001. PMID: 11296271 Free PMC article.

2

Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.

Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL. Fontes AM, et al. Among authors: loeb la. Mol Cancer Ther. 2006 Jan;5(1):121-8. doi: 10.1158/1535-7163.MCT-05-0236. Mol Cancer Ther. 2006. PMID: 16432170

3

Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria.

Christians FC, Loeb LA. Christians FC, et al. Among authors: loeb la. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6124-8. doi: 10.1073/pnas.93.12.6124. Proc Natl Acad Sci U S A. 1996. PMID: 8650230 Free PMC article.

4

Creation of human alkyltransferases resistant to O6-benzylguanine.

Christians FC, Dawson BJ, Coates MM, Loeb LA. Christians FC, et al. Among authors: loeb la. Cancer Res. 1997 May 15;57(10):2007-12. Cancer Res. 1997. PMID: 9157998

5

Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis.

Encell LP, Coates MM, Loeb LA. Encell LP, et al. Among authors: loeb la. Cancer Res. 1998 Mar 1;58(5):1013-20. Cancer Res. 1998. PMID: 9500464

6

Redesigning the substrate specificity of human O(6)-alkylguanine-DNA alkyltransferase. Mutants with enhanced repair of O(4)-methylthymine.

Encell LP, Loeb LA. Encell LP, et al. Among authors: loeb la. Biochemistry. 1999 Sep 14;38(37):12097-103. doi: 10.1021/bi9913606. Biochemistry. 1999. PMID: 10508414

7

Human O(6)-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes.

Abril N, Luque-Romero FL, Christians FC, Encell LP, Loeb LA, Pueyo C. Abril N, et al. Among authors: loeb la. Carcinogenesis. 1999 Nov;20(11):2089-94. doi: 10.1093/carcin/20.11.2089. Carcinogenesis. 1999. PMID: 10545410

8

Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.

Encell LP, Loeb LA. Encell LP, et al. Among authors: loeb la. Carcinogenesis. 2000 Jul;21(7):1397-402. Carcinogenesis. 2000. PMID: 10874019

9

Creating novel enzymes by applied molecular evolution.

Skandalis A, Encell LP, Loeb LA. Skandalis A, et al. Among authors: loeb la. Chem Biol. 1997 Dec;4(12):889-98. doi: 10.1016/s1074-5521(97)90297-0. Chem Biol. 1997. PMID: 9427661 Review.

10

Improving enzymes for cancer gene therapy.

Encell LP, Landis DM, Loeb LA. Encell LP, et al. Among authors: loeb la. Nat Biotechnol. 1999 Feb;17(2):143-7. doi: 10.1038/6142. Nat Biotechnol. 1999. PMID: 10052349 Review.

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