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Progress toward the development of a safe and effective agent for treating reentrant cardiac arrhythmias: synthesis and evaluation of ibutilide analogues with enhanced metabolic stability and diminished proarrhythmic potential.
Hester JB, Gibson JK, Buchanan LV, Cimini MG, Clark MA, Emmert DE, Glavanovich MA, Imbordino RJ, LeMay RJ, McMillan MW, Perricone SC, Squires DM, Walters RR. Hester JB, et al. Among authors: imbordino rj. J Med Chem. 2001 Mar 29;44(7):1099-115. doi: 10.1021/jm0004289. J Med Chem. 2001. PMID: 11297456