Li H - Search Results

1

Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.

Raman CS, Li H, Martásek P, Babu BR, Griffith OW, Masters BS, Poulos TL. Raman CS, et al. Among authors: li h. J Biol Chem. 2001 Jul 13;276(28):26486-91. doi: 10.1074/jbc.M102255200. Epub 2001 Apr 30. J Biol Chem. 2001. PMID: 11331290 Free article.

Isothioureas are potent NOS inhibitors, and the structures of the endothelial NOS heme domain complexed with isothioureas bearing small S-alkyl substituents have been determined (Li, H., Raman, C.S., Martasek, P., Kral, V., Masters, B.S.S., and Poulos, T.L. (2000) J …

Isothioureas are potent NOS inhibitors, and the structures of the endothelial NOS heme domain complexed with isothioureas bearing small S-al …

2

Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.

Li H, Raman CS, Martásek P, Král V, Masters BS, Poulos TL. Li H, et al. J Inorg Biochem. 2000 Aug 31;81(3):133-9. doi: 10.1016/s0162-0134(00)00099-4. J Inorg Biochem. 2000. PMID: 11051558

3

Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.

Li H, Raman CS, Martásek P, Masters BS, Poulos TL. Li H, et al. Biochemistry. 2001 May 8;40(18):5399-406. doi: 10.1021/bi002658v. Biochemistry. 2001. PMID: 11331003

4

Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin.

Kotsonis P, Fröhlich LG, Raman CS, Li H, Berg M, Gerwig R, Groehn V, Kang Y, Al-Masoudi N, Taghavi-Moghadam S, Mohr D, Münch U, Schnabel J, Martásek P, Masters BS, Strobel H, Poulos T, Matter H, Pfleiderer W, Schmidt HH. Kotsonis P, et al. Among authors: li h. J Biol Chem. 2001 Dec 28;276(52):49133-41. doi: 10.1074/jbc.M011469200. Epub 2001 Oct 5. J Biol Chem. 2001. PMID: 11590164 Free article.

5

Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.

Raman CS, Li H, Martásek P, Southan G, Masters BS, Poulos TL. Raman CS, et al. Among authors: li h. Biochemistry. 2001 Nov 13;40(45):13448-55. doi: 10.1021/bi010957u. Biochemistry. 2001. PMID: 11695891

6

Conformational dynamics in cytochrome P450-substrate interactions.

Li H, Poulos TL. Li H, et al. Biochimie. 1996;78(8-9):695-9. doi: 10.1016/s0300-9084(97)82526-6. Biochimie. 1996. PMID: 9010597

7

NO news is good news.

Poulos TL, Raman CS, Li H. Poulos TL, et al. Among authors: li h. Structure. 1998 Mar 15;6(3):255-8. doi: 10.1016/s0969-2126(98)00028-8. Structure. 1998. PMID: 9551547 Free article. Review.

8

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center.

Raman CS, Li H, Martásek P, Král V, Masters BS, Poulos TL. Raman CS, et al. Among authors: li h. Cell. 1998 Dec 23;95(7):939-50. doi: 10.1016/s0092-8674(00)81718-3. Cell. 1998. PMID: 9875848 Free article.

9

Heme-mediated oxygen activation in biology: cytochrome c oxidase and nitric oxide synthase.

Poulos TL, Li H, Raman CS. Poulos TL, et al. Among authors: li h. Curr Opin Chem Biol. 1999 Apr;3(2):131-7. doi: 10.1016/s1367-5931(99)80024-6. Curr Opin Chem Biol. 1999. PMID: 10348620 Review.

10

Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase.

Li H, Raman CS, Glaser CB, Blasko E, Young TA, Parkinson JF, Whitlow M, Poulos TL. Li H, et al. J Biol Chem. 1999 Jul 23;274(30):21276-84. doi: 10.1074/jbc.274.30.21276. J Biol Chem. 1999. PMID: 10409685 Free article.

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