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Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells.
van Der Velden VH, te Marvelde JG, Hoogeveen PG, Bernstein ID, Houtsmuller AB, Berger MS, van Dongen JJ. van Der Velden VH, et al. Among authors: bernstein id. Blood. 2001 May 15;97(10):3197-204. doi: 10.1182/blood.v97.10.3197. Blood. 2001. PMID: 11342449 Free article. Clinical Trial.
CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy.
Walter RB, Gooley TA, van der Velden VH, Loken MR, van Dongen JJ, Flowers DA, Bernstein ID, Appelbaum FR. Walter RB, et al. Among authors: bernstein id. Blood. 2007 May 15;109(10):4168-70. doi: 10.1182/blood-2006-09-047399. Epub 2007 Jan 16. Blood. 2007. PMID: 17227830 Free PMC article.
Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse.
Sievers EL, Larson RA, Stadtmauer EA, Estey E, Löwenberg B, Dombret H, Karanes C, Theobald M, Bennett JM, Sherman ML, Berger MS, Eten CB, Loken MR, van Dongen JJ, Bernstein ID, Appelbaum FR; Mylotarg Study Group. Sievers EL, et al. Among authors: bernstein id. J Clin Oncol. 2001 Jul 1;19(13):3244-54. doi: 10.1200/JCO.2001.19.13.3244. J Clin Oncol. 2001. PMID: 11432892 Clinical Trial.
Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin).
Larson RA, Boogaerts M, Estey E, Karanes C, Stadtmauer EA, Sievers EL, Mineur P, Bennett JM, Berger MS, Eten CB, Munteanu M, Loken MR, Van Dongen JJ, Bernstein ID, Appelbaum FR; Mylotarg Study Group. Larson RA, et al. Among authors: bernstein id. Leukemia. 2002 Sep;16(9):1627-36. doi: 10.1038/sj.leu.2402677. Leukemia. 2002. PMID: 12200674 Clinical Trial.
Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence.
Larson RA, Sievers EL, Stadtmauer EA, Löwenberg B, Estey EH, Dombret H, Theobald M, Voliotis D, Bennett JM, Richie M, Leopold LH, Berger MS, Sherman ML, Loken MR, van Dongen JJ, Bernstein ID, Appelbaum FR. Larson RA, et al. Among authors: bernstein id. Cancer. 2005 Oct 1;104(7):1442-52. doi: 10.1002/cncr.21326. Cancer. 2005. PMID: 16116598 Free article.
Simultaneously targeting CD45 significantly increases cytotoxicity of the anti-CD33 immunoconjugate, gemtuzumab ozogamicin, against acute myeloid leukemia (AML) cells and improves survival of mice bearing human AML xenografts.
Walter RB, Boyle KM, Appelbaum FR, Bernstein ID, Pagel JM. Walter RB, et al. Among authors: bernstein id. Blood. 2008 May 1;111(9):4813-6. doi: 10.1182/blood-2008-01-133785. Epub 2008 Mar 7. Blood. 2008. PMID: 18326813 Free PMC article.
Acute myeloid leukemia stem cells and CD33-targeted immunotherapy.
Walter RB, Appelbaum FR, Estey EH, Bernstein ID. Walter RB, et al. Among authors: bernstein id. Blood. 2012 Jun 28;119(26):6198-208. doi: 10.1182/blood-2011-11-325050. Epub 2012 Jan 27. Blood. 2012. PMID: 22286199 Free PMC article. Review.
245 results