Stalder H - Search Results

1

2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.

Apfel C, Banner DW, Bur D, Dietz M, Hubschwerlen C, Locher H, Marlin F, Masciadri R, Pirson W, Stalder H. Apfel C, et al. Among authors: stalder h. J Med Chem. 2001 Jun 7;44(12):1847-52. doi: 10.1021/jm000352g. J Med Chem. 2001. PMID: 11384231

2

Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci.

Heinze-Krauss I, Angehrn P, Guerry P, Hebeisen P, Hubschwerlen C, Kompis I, Page MG, Richter HG, Runtz V, Stalder H, Weiss U, Wei CC. Heinze-Krauss I, et al. Among authors: stalder h. J Med Chem. 1996 Apr 26;39(9):1864-71. doi: 10.1021/jm950886v. J Med Chem. 1996. PMID: 8627610

3

Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors.

Pinard E, Alberati D, Borroni E, Fischer H, Hainzl D, Jolidon S, Moreau JL, Narquizian R, Nettekoven M, Norcross RD, Stalder H, Thomas AW. Pinard E, et al. Among authors: stalder h. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5134-9. doi: 10.1016/j.bmcl.2008.07.086. Epub 2008 Jul 24. Bioorg Med Chem Lett. 2008. PMID: 18752953

4

Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.

Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, Brom V, Burner S, Fischer H, Hainzl D, Halm R, Hauser N, Jolidon S, Lengyel J, Marty HP, Meyer T, Moreau JL, Mory R, Narquizian R, Nettekoven M, Norcross RD, Puellmann B, Schmid P, Schmitt S, Stalder H, Wermuth R, Wettstein JG, Zimmerli D. Pinard E, et al. Among authors: stalder h. J Med Chem. 2010 Jun 24;53(12):4603-14. doi: 10.1021/jm100210p. J Med Chem. 2010. PMID: 20491477

5

Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773).

Stalder H, Hoener MC, Norcross RD. Stalder H, et al. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1227-31. doi: 10.1016/j.bmcl.2010.12.075. Epub 2010 Dec 21. Bioorg Med Chem Lett. 2011. PMID: 21237643

6

Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors.

Pinard E, Ceccarelli SM, Stalder H, Alberati D. Pinard E, et al. Among authors: stalder h. Bioorg Med Chem Lett. 2006 Jan 15;16(2):349-53. doi: 10.1016/j.bmcl.2005.09.075. Epub 2005 Oct 21. Bioorg Med Chem Lett. 2006. PMID: 16246557

7

3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors.

Pinard E, Alberati D, Alvarez-Sanchez R, Brom V, Burner S, Fischer H, Hauser N, Kolczewski S, Lengyel J, Mory R, Saladin C, Schulz-Gasch T, Stalder H. Pinard E, et al. Among authors: stalder h. ACS Med Chem Lett. 2014 Feb 4;5(4):428-33. doi: 10.1021/ml500005m. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900853 Free PMC article.

8

Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile.

Ceccarelli SM, Pinard E, Stalder H, Alberati D. Ceccarelli SM, et al. Among authors: stalder h. Bioorg Med Chem Lett. 2006 Jan 15;16(2):354-7. doi: 10.1016/j.bmcl.2005.09.067. Epub 2005 Oct 21. Bioorg Med Chem Lett. 2006. PMID: 16246561

9

Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012.

Galley G, Stalder H, Goergler A, Hoener MC, Norcross RD. Galley G, et al. Among authors: stalder h. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. doi: 10.1016/j.bmcl.2012.06.060. Epub 2012 Jun 23. Bioorg Med Chem Lett. 2012. PMID: 22795332

10

Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: achieving selectivity against the mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors.

Alberati D, Ceccarelli SM, Jolidon S, Krafft EA, Kurt A, Maier A, Pinard E, Stalder H, Studer D, Thomas AW, Zimmerli D. Alberati D, et al. Among authors: stalder h. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4305-10. doi: 10.1016/j.bmcl.2006.05.064. Epub 2006 Jun 9. Bioorg Med Chem Lett. 2006. PMID: 16762548

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