Spalding T - Search Results

1

Exploring the potential for subtype-selective muscarinic agonists in glaucoma.

Gil D, Spalding T, Kharlamb A, Skjaerbaek N, Uldam A, Trotter C, Li D, WoldeMussie E, Wheeler L, Brann M. Gil D, et al. Among authors: spalding t. Life Sci. 2001 Apr 27;68(22-23):2601-4. doi: 10.1016/s0024-3205(01)01058-x. Life Sci. 2001. PMID: 11392632

2

Discovery of an ectopic activation site on the M(1) muscarinic receptor.

Spalding TA, Trotter C, Skjaerbaek N, Messier TL, Currier EA, Burstein ES, Li D, Hacksell U, Brann MR. Spalding TA, et al. Mol Pharmacol. 2002 Jun;61(6):1297-302. doi: 10.1124/mol.61.6.1297. Mol Pharmacol. 2002. PMID: 12021390

3

Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins.

Burstein ES, Spalding TA, Brann MR. Burstein ES, et al. Among authors: spalding ta. Mol Pharmacol. 1997 Feb;51(2):312-9. doi: 10.1124/mol.51.2.312. Mol Pharmacol. 1997. PMID: 9203637

4

Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6.

Spalding TA, Burstein ES, Wells JW, Brann MR. Spalding TA, et al. Biochemistry. 1997 Aug 19;36(33):10109-16. doi: 10.1021/bi970565g. Biochemistry. 1997. PMID: 9254607

5

Identification of a ligand-dependent switch within a muscarinic receptor.

Spalding TA, Burstein ES, Henderson SC, Ducote KR, Brann MR. Spalding TA, et al. J Biol Chem. 1998 Aug 21;273(34):21563-8. doi: 10.1074/jbc.273.34.21563. J Biol Chem. 1998. PMID: 9705286 Free article.

6

Constitutive activation of muscarinic receptors by the G-protein Gq.

Burstein ES, Spalding TA, Braüner-Osborne H, Brann MR. Burstein ES, et al. Among authors: spalding ta. FEBS Lett. 1995 Apr 24;363(3):261-3. doi: 10.1016/0014-5793(95)00323-2. FEBS Lett. 1995. PMID: 7737412 Free article.

7

Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals.

Burstein ES, Bräuner-Osborne H, Spalding TA, Conklin BR, Brann MR. Burstein ES, et al. Among authors: spalding ta. J Neurochem. 1997 Feb;68(2):525-33. doi: 10.1046/j.1471-4159.1997.68020525.x. J Neurochem. 1997. PMID: 9003037 Free article.

8

Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis.

Spalding TA, Burstein ES, Brauner-Osborne H, Hill-Eubanks D, Brann MR. Spalding TA, et al. J Pharmacol Exp Ther. 1995 Dec;275(3):1274-9. J Pharmacol Exp Ther. 1995. PMID: 8531092

9

Structure/function relationships of a G-protein coupling pocket formed by the third intracellular loop of the m5 muscarinic receptor.

Burstein ES, Spalding TA, Brann MR. Burstein ES, et al. Among authors: spalding ta. Biochemistry. 1998 Mar 24;37(12):4052-8. doi: 10.1021/bi972132j. Biochemistry. 1998. PMID: 9521726

Using random saturation mutagenesis, we have previously identified the amino acids K439, A440, and A441 in the C-terminus of the third intracellular loop (Ci3) of the m5 muscarinic receptor as being critical for G-protein coupling [Burstein, E. S., Spalding, T. A., …

Using random saturation mutagenesis, we have previously identified the amino acids K439, A440, and A441 in the C-terminus of the third intra …

10

Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: evidence for three distinct modes of receptor activation.

Spalding TA, Ma JN, Ott TR, Friberg M, Bajpai A, Bradley SR, Davis RE, Brann MR, Burstein ES. Spalding TA, et al. Mol Pharmacol. 2006 Dec;70(6):1974-83. doi: 10.1124/mol.106.024901. Epub 2006 Sep 7. Mol Pharmacol. 2006. PMID: 16959945

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