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New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures.
Gebhardt R, Hengstler JG, Müller D, Glöckner R, Buenning P, Laube B, Schmelzer E, Ullrich M, Utesch D, Hewitt N, Ringel M, Hilz BR, Bader A, Langsch A, Koose T, Burger HJ, Maas J, Oesch F. Gebhardt R, et al. Drug Metab Rev. 2003 May-Aug;35(2-3):145-213. doi: 10.1081/dmr-120023684. Drug Metab Rev. 2003. PMID: 12959414 Review.
Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.
Hewitt NJ, Lechón MJ, Houston JB, Hallifax D, Brown HS, Maurel P, Kenna JG, Gustavsson L, Lohmann C, Skonberg C, Guillouzo A, Tuschl G, Li AP, LeCluyse E, Groothuis GM, Hengstler JG. Hewitt NJ, et al. Drug Metab Rev. 2007;39(1):159-234. doi: 10.1080/03602530601093489. Drug Metab Rev. 2007. PMID: 17364884 Review.
Cryopreservation of Hepatocytes.
Hewitt NJ, Li AP. Hewitt NJ, et al. Methods Mol Biol. 2015;1250:13-26. doi: 10.1007/978-1-4939-2074-7_2. Methods Mol Biol. 2015. PMID: 26272132
93 results