Slaughter RS - Search Results

1

Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3.

Singh SB, Zink DL, Dombrowski AW, Dezeny G, Bills GF, Felix JP, Slaughter RS, Goetz MA. Singh SB, et al. Among authors: slaughter rs. Org Lett. 2001 Jan 25;3(2):247-50. doi: 10.1021/ol006891x. Org Lett. 2001. PMID: 11430046

2

Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3.

Felix JP, Bugianesi RM, Schmalhofer WA, Borris R, Goetz MA, Hensens OD, Bao JM, Kayser F, Parsons WH, Rupprecht K, Garcia ML, Kaczorowski GJ, Slaughter RS. Felix JP, et al. Among authors: slaughter rs. Biochemistry. 1999 Apr 20;38(16):4922-30. doi: 10.1021/bi982954w. Biochemistry. 1999. PMID: 10213593

3

Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties.

Schmalhofer WA, Bao J, McManus OB, Green B, Matyskiela M, Wunderler D, Bugianesi RM, Felix JP, Hanner M, Linde-Arias AR, Ponte CG, Velasco L, Koo G, Staruch MJ, Miao S, Parsons WH, Rupprecht K, Slaughter RS, Kaczorowski GJ, Garcia ML. Schmalhofer WA, et al. Among authors: slaughter rs. Biochemistry. 2002 Jun 18;41(24):7781-94. doi: 10.1021/bi025722c. Biochemistry. 2002. PMID: 12056910

4

Di-substituted cyclohexyl derivatives bind to two identical sites with positive cooperativity on the voltage-gated potassium channel, K(v)1.3.

Schmalhofer WA, Slaughter RS, Matyskiela M, Felix JP, Tang YS, Rupprecht K, Kaczorowski GJ, Garcia ML. Schmalhofer WA, et al. Among authors: slaughter rs. Biochemistry. 2003 Apr 29;42(16):4733-43. doi: 10.1021/bi034122q. Biochemistry. 2003. PMID: 12705837

5

Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.

Felix JP, Williams BS, Priest BT, Brochu RM, Dick IE, Warren VA, Yan L, Slaughter RS, Kaczorowski GJ, Smith MM, Garcia ML. Felix JP, et al. Among authors: slaughter rs. Assay Drug Dev Technol. 2004 Jun;2(3):260-8. doi: 10.1089/1540658041410696. Assay Drug Dev Technol. 2004. PMID: 15285907

6

Potent Kv1.3 inhibitors from correolide-modification of the C18 position.

Bao J, Miao S, Kayser F, Kotliar AJ, Baker RK, Doss GA, Felix JP, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Garcia ML, Ha SN, Castonguay L, Koo GC, Shah K, Springer MS, Staruch MJ, Parsons WH, Rupprecht KM. Bao J, et al. Among authors: slaughter rs. Bioorg Med Chem Lett. 2005 Jan 17;15(2):447-51. doi: 10.1016/j.bmcl.2004.10.058. Bioorg Med Chem Lett. 2005. PMID: 15603971

7

Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo.

Koo GC, Blake JT, Talento A, Nguyen M, Lin S, Sirotina A, Shah K, Mulvany K, Hora D Jr, Cunningham P, Wunderler DL, McManus OB, Slaughter R, Bugianesi R, Felix J, Garcia M, Williamson J, Kaczorowski G, Sigal NH, Springer MS, Feeney W. Koo GC, et al. J Immunol. 1997 Jun 1;158(11):5120-8. J Immunol. 1997. PMID: 9164927

8

Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells.

Helms LM, Felix JP, Bugianesi RM, Garcia ML, Stevens S, Leonard RJ, Knaus HG, Koch R, Wanner SG, Kaczorowski GJ, Slaughter RS. Helms LM, et al. Among authors: slaughter rs. Biochemistry. 1997 Mar 25;36(12):3737-44. doi: 10.1021/bi962351p. Biochemistry. 1997. PMID: 9132027

9

Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.

Middleton RE, Sanchez M, Linde AR, Bugianesi RM, Dai G, Felix JP, Koprak SL, Staruch MJ, Bruguera M, Cox R, Ghosh A, Hwang J, Jones S, Kohler M, Slaughter RS, McManus OB, Kaczorowski GJ, Garcia ML. Middleton RE, et al. Among authors: slaughter rs. Biochemistry. 2003 Nov 25;42(46):13698-707. doi: 10.1021/bi035209e. Biochemistry. 2003. PMID: 14622016

10

Bis(benzylisoquinoline) analogs of tetrandrine block L-type calcium channels: evidence for interaction at the diltiazem-binding site.

Felix JP, King VF, Shevell JL, Garcia ML, Kaczorowski GJ, Bick IR, Slaughter RS. Felix JP, et al. Among authors: slaughter rs. Biochemistry. 1992 Dec 1;31(47):11793-800. doi: 10.1021/bi00162a017. Biochemistry. 1992. PMID: 1332772

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