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A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.
Bonafè M, Olivieri F, Cavallone L, Giovagnetti S, Mayegiani F, Cardelli M, Pieri C, Marra M, Antonicelli R, Lisa R, Rizzo MR, Paolisso G, Monti D, Franceschi C. Bonafè M, et al. Among authors: antonicelli r. Eur J Immunol. 2001 Aug;31(8):2357-61. doi: 10.1002/1521-4141(200108)31:8<2357::aid-immu2357>3.0.co;2-x. Eur J Immunol. 2001. PMID: 11500818 Free article.
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.
Bonafè M, Marchegiani F, Cardelli M, Olivieri F, Cavallone L, Giovagnetti S, Pieri C, Marra M, Antonicelli R, Troiano L, Gueresi P, Passeri G, Berardelli M, Paolisso G, Barbieri M, Tesei S, Lisa R, De Benedictis G, Franceschi C. Bonafè M, et al. Among authors: antonicelli r. Eur J Hum Genet. 2002 May;10(5):292-6. doi: 10.1038/sj.ejhg.5200806. Eur J Hum Genet. 2002. PMID: 12082503
The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.
Bonafé M, Salvioli S, Barbi C, Trapassi C, Tocco F, Storci G, Invidia L, Vannini I, Rossi M, Marzi E, Mishto M, Capri M, Olivieri F, Antonicelli R, Memo M, Uberti D, Nacmias B, Sorbi S, Monti D, Franceschi C. Bonafé M, et al. Among authors: antonicelli r. Cell Death Differ. 2004 Sep;11(9):962-73. doi: 10.1038/sj.cdd.4401415. Cell Death Differ. 2004. PMID: 15131588
Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients.
Testa R, Olivieri F, Bonfigli AR, Sirolla C, Boemi M, Marchegiani F, Marra M, Cenerelli S, Antonicelli R, Dolci A, Paolisso G, Franceschi C. Testa R, et al. Among authors: antonicelli r. Diabetes Res Clin Pract. 2006 Mar;71(3):299-305. doi: 10.1016/j.diabres.2005.07.007. Epub 2005 Sep 2. Diabetes Res Clin Pract. 2006. PMID: 16140413
152 results