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Synthesis of a muscarinic receptor antagonist via a diastereoselective Michael reaction, selective deoxyfluorination and aromatic metal-halogen exchange reaction.
Mase T, Houpis IN, Akao A, Dorziotis I, Emerson K, Hoang T, Iida T, Itoh T, Kamei K, Kato S, Kato Y, Kawasaki M, Lang F, Lee J, Lynch J, Maligres P, Molina A, Nemoto T, Okada S, Reamer R, Song JZ, Tschaen D, Wada T, Zewge D, Volante RP, Reider PJ, Tomimoto K. Mase T, et al. Among authors: emerson k. J Org Chem. 2001 Oct 5;66(20):6775-86. doi: 10.1021/jo0157425. J Org Chem. 2001. PMID: 11578234
Highly Chemoselective Trichloroacetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosuppressant L-733,725.
Song Z, DeMarco A, Zhao M, Corley EG, Thompson AS, McNamara J, Li Y, Rieger D, Sohar P, Mathre DJ, Tschaen DM, Reamer RA, Huntington MF, Ho GJ, Tsay FR, Emerson K, Shuman R, Grabowski EJ, Reider PJ. Song Z, et al. Among authors: emerson k. J Org Chem. 1999 Mar 19;64(6):1859-1867. doi: 10.1021/jo981805g. J Org Chem. 1999. PMID: 11674275
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19.
Fier PS, Xu Y, Poirier M, Brito G, Zheng M, Bade R, Sirota E, Stone K, Tan L, Humphrey GR, Chang D, Bothe J, Zhang Y, Bernardoni F, Castro S, Zompa MA, Taylor J, Sirk KM, Diaz-Santana A, Diribe I, Emerson KM, Krishnamurthi B, Zhao R, Ward M, Xiao C, Ouyand H, Zhan J, Morris WJ. Fier PS, et al. Among authors: emerson km. Org Process Res Dev. 2021 Dec 17;25(12):2806-2815. doi: 10.1021/acs.oprd.1c00400. Epub 2021 Dec 10. Org Process Res Dev. 2021. PMID: 35095257 Review.
140 results