Coxon FP - Search Results

1

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

Coxon FP, Helfrich MH, Larijani B, Muzylak M, Dunford JE, Marshall D, McKinnon AD, Nesbitt SA, Horton MA, Seabra MC, Ebetino FH, Rogers MJ. Coxon FP, et al. J Biol Chem. 2001 Dec 21;276(51):48213-22. doi: 10.1074/jbc.M106473200. Epub 2001 Oct 1. J Biol Chem. 2001. PMID: 11581260 Free article.

2

Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo.

Coxon FP, Ebetino FH, Mules EH, Seabra MC, McKenna CE, Rogers MJ. Coxon FP, et al. Bone. 2005 Sep;37(3):349-58. doi: 10.1016/j.bone.2005.04.021. Bone. 2005. PMID: 16006204

3

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

Dunford JE, Rogers MJ, Ebetino FH, Phipps RJ, Coxon FP. Dunford JE, et al. Among authors: coxon fp. J Bone Miner Res. 2006 May;21(5):684-94. doi: 10.1359/jbmr.060118. J Bone Miner Res. 2006. PMID: 16734383 Free article.

4

Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.

Coxon FP, Thompson K, Roelofs AJ, Ebetino FH, Rogers MJ. Coxon FP, et al. Bone. 2008 May;42(5):848-60. doi: 10.1016/j.bone.2007.12.225. Epub 2008 Jan 26. Bone. 2008. PMID: 18325866

5

Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.

Baron RA, Tavaré R, Figueiredo AC, Błazewska KM, Kashemirov BA, McKenna CE, Ebetino FH, Taylor A, Rogers MJ, Coxon FP, Seabra MC. Baron RA, et al. Among authors: coxon fp. J Biol Chem. 2009 Mar 13;284(11):6861-8. doi: 10.1074/jbc.M806952200. Epub 2008 Dec 11. J Biol Chem. 2009. PMID: 19074143 Free PMC article.

6

The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates.

Coxon FP, Taylor A, Stewart CA, Baron R, Seabra MC, Ebetino FH, Rogers MJ. Coxon FP, et al. Bone. 2011 Jul;49(1):111-21. doi: 10.1016/j.bone.2011.03.686. Epub 2011 Mar 21. Bone. 2011. PMID: 21419243

7

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

Luckman SP, Coxon FP, Ebetino FH, Russell RG, Rogers MJ. Luckman SP, et al. Among authors: coxon fp. J Bone Miner Res. 1998 Nov;13(11):1668-78. doi: 10.1359/jbmr.1998.13.11.1668. J Bone Miner Res. 1998. PMID: 9797474 Free article.

8

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ. Dunford JE, et al. Among authors: coxon fp. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42. J Pharmacol Exp Ther. 2001. PMID: 11160603

9

Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.

Marma MS, Xia Z, Stewart C, Coxon F, Dunford JE, Baron R, Kashemirov BA, Ebetino FH, Triffitt JT, Russell RG, McKenna CE. Marma MS, et al. J Med Chem. 2007 Nov 29;50(24):5967-75. doi: 10.1021/jm0702884. Epub 2007 Nov 2. J Med Chem. 2007. PMID: 17975902

10

Recent advances in understanding the mechanism of action of bisphosphonates.

Coxon FP, Thompson K, Rogers MJ. Coxon FP, et al. Curr Opin Pharmacol. 2006 Jun;6(3):307-12. doi: 10.1016/j.coph.2006.03.005. Epub 2006 May 2. Curr Opin Pharmacol. 2006. PMID: 16650801 Review.

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