Rusnak DW - Search Results

1

The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.

Rusnak DW, Affleck K, Cockerill SG, Stubberfield C, Harris R, Page M, Smith KJ, Guntrip SB, Carter MC, Shaw RJ, Jowett A, Stables J, Topley P, Wood ER, Brignola PS, Kadwell SH, Reep BR, Mullin RJ, Alligood KJ, Keith BR, Crosby RM, Murray DM, Knight WB, Gilmer TM, Lackey K. Rusnak DW, et al. Cancer Res. 2001 Oct 1;61(19):7196-203. Cancer Res. 2001. PMID: 11585755

2

Synthesis and SAR of potent EGFR/erbB2 dual inhibitors.

Zhang YM, Cockerill S, Guntrip SB, Rusnak D, Smith K, Vanderwall D, Wood E, Lackey K. Zhang YM, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):111-4. doi: 10.1016/j.bmcl.2003.10.010. Bioorg Med Chem Lett. 2004. PMID: 14684309

3

Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib.

Gilmer TM, Cable L, Alligood K, Rusnak D, Spehar G, Gallagher KT, Woldu E, Carter HL, Truesdale AT, Shewchuk L, Wood ER. Gilmer TM, et al. Cancer Res. 2008 Jan 15;68(2):571-9. doi: 10.1158/0008-5472.CAN-07-2404. Cancer Res. 2008. PMID: 18199554

4

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways.

Xia W, Mullin RJ, Keith BR, Liu LH, Ma H, Rusnak DW, Owens G, Alligood KJ, Spector NL. Xia W, et al. Among authors: rusnak dw. Oncogene. 2002 Sep 12;21(41):6255-63. doi: 10.1038/sj.onc.1205794. Oncogene. 2002. PMID: 12214266

5

Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.

Gaul MD, Guo Y, Affleck K, Cockerill GS, Gilmer TM, Griffin RJ, Guntrip S, Keith BR, Knight WB, Mullin RJ, Murray DM, Rusnak DW, Smith K, Tadepalli S, Wood ER, Lackey K. Gaul MD, et al. Among authors: rusnak dw. Bioorg Med Chem Lett. 2003 Feb 24;13(4):637-40. doi: 10.1016/s0960-894x(02)01047-8. Bioorg Med Chem Lett. 2003. PMID: 12639547

6

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.

Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L. Wood ER, et al. Among authors: rusnak dw. Cancer Res. 2004 Sep 15;64(18):6652-9. doi: 10.1158/0008-5472.CAN-04-1168. Cancer Res. 2004. PMID: 15374980

7

Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series.

Petrov KG, Zhang YM, Carter M, Cockerill GS, Dickerson S, Gauthier CA, Guo Y, Mook RA Jr, Rusnak DW, Walker AL, Wood ER, Lackey KE. Petrov KG, et al. Among authors: rusnak dw. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4686-91. doi: 10.1016/j.bmcl.2006.05.090. Epub 2006 Jun 13. Bioorg Med Chem Lett. 2006. PMID: 16777410

8

The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

Rusnak DW, Lackey K, Affleck K, Wood ER, Alligood KJ, Rhodes N, Keith BR, Murray DM, Knight WB, Mullin RJ, Gilmer TM. Rusnak DW, et al. Mol Cancer Ther. 2001 Dec;1(2):85-94. Mol Cancer Ther. 2001. PMID: 12467226

9

The discovery of lapatinib (GW572016).

Rusnak D, Gilmer TM. Rusnak D, et al. Mol Cancer Ther. 2011 Nov;10(11):2019. doi: 10.1158/1535-7163.MCT-11-0697. Mol Cancer Ther. 2011. PMID: 22072804 No abstract available.

10

Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles.

Hegde PS, Rusnak D, Bertiaux M, Alligood K, Strum J, Gagnon R, Gilmer TM. Hegde PS, et al. Mol Cancer Ther. 2007 May;6(5):1629-40. doi: 10.1158/1535-7163.MCT-05-0399. Mol Cancer Ther. 2007. PMID: 17513611

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