Hase Y - Search Results

1

Catalytic Asymmetric Aminolysis of 3,5,8-Trioxabicyclo[5.1.0]octane Providing an Optically Pure 2-Amino-1,3,4-butanetriol Equivalent.

Sagawa S, Abe H, Hase Y, Inaba T. Sagawa S, et al. Among authors: hase y. J Org Chem. 1999 Jun 25;64(13):4962-4965. doi: 10.1021/jo9900883. J Org Chem. 1999. PMID: 11674582 No abstract available.

2

Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCbeta-selective inhibitors.

Tanaka M, Sagawa S, Hoshi J, Shimoma F, Yasue K, Ubukata M, Ikemoto T, Hase Y, Takahashi M, Sasase T, Ueda N, Matsushita M, Inaba T. Tanaka M, et al. Among authors: hase y. Bioorg Med Chem. 2006 Sep 1;14(17):5781-94. doi: 10.1016/j.bmc.2006.05.033. Epub 2006 Jun 9. Bioorg Med Chem. 2006. PMID: 16762554

3

Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors.

Shiozaki M, Maeda K, Miura T, Kotoku M, Yamasaki T, Matsuda I, Aoki K, Yasue K, Imai H, Ubukata M, Suma A, Yokota M, Hotta T, Tanaka M, Hase Y, Haas J, Fryer AM, Laird ER, Littmann NM, Andrews SW, Josey JA, Mimura T, Shinozaki Y, Yoshiuchi H, Inaba T. Shiozaki M, et al. Among authors: hase y. J Med Chem. 2011 Apr 28;54(8):2839-63. doi: 10.1021/jm101609j. Epub 2011 Mar 21. J Med Chem. 2011. PMID: 21417219

4

Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia.

Ogoshi Y, Matsui T, Mitani I, Yokota M, Terashita M, Motoda D, Ueyama K, Hotta T, Ito T, Hase Y, Fukui K, Deai K, Yoshiuchi H, Ito S, Abe H. Ogoshi Y, et al. Among authors: hase y. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325. doi: 10.1021/acsmedchemlett.7b00404. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259755 Free PMC article.

5

Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine derivatives: novel arginine vasopressin antagonists.

Cho H, Murakami K, Nakanishi H, Fujisawa A, Isoshima H, Niwa M, Hayakawa K, Hase Y, Uchida I, Watanabe H, Wakitani K, Aisaka K. Cho H, et al. Among authors: hase y. J Med Chem. 2004 Jan 1;47(1):101-9. doi: 10.1021/jm030287l. J Med Chem. 2004. PMID: 14695824

6

Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring.

Ueno H, Yokota K, Hoshi J, Yasue K, Hayashi M, Hase Y, Uchida I, Aisaka K, Katoh S, Cho H. Ueno H, et al. Among authors: hase y. J Med Chem. 2005 May 19;48(10):3586-604. doi: 10.1021/jm058160e. J Med Chem. 2005. PMID: 15887966

7

Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.

Ikegashira K, Oka T, Hirashima S, Noji S, Yamanaka H, Hara Y, Adachi T, Tsuruha J, Doi S, Hase Y, Noguchi T, Ando I, Ogura N, Ikeda S, Hashimoto H. Ikegashira K, et al. Among authors: hase y. J Med Chem. 2006 Nov 30;49(24):6950-3. doi: 10.1021/jm0610245. J Med Chem. 2006. PMID: 17125247

8

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.

Noji S, Hara Y, Miura T, Yamanaka H, Maeda K, Hori A, Yamamoto H, Obika S, Inoue M, Hase Y, Orita T, Doi S, Adachi T, Tanimoto A, Oki C, Kimoto Y, Ogawa Y, Negoro T, Hashimoto H, Shiozaki M. Noji S, et al. Among authors: hase y. J Med Chem. 2020 Jul 9;63(13):7163-7185. doi: 10.1021/acs.jmedchem.0c00450. Epub 2020 Jun 29. J Med Chem. 2020. PMID: 32511913

9

Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa.

Ueno H, Katoh S, Yokota K, Hoshi J, Hayashi M, Uchida I, Aisaka K, Hase Y, Cho H. Ueno H, et al. Among authors: hase y. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4281-6. doi: 10.1016/j.bmcl.2004.05.092. Bioorg Med Chem Lett. 2004. PMID: 15261287

10

Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors.

Ueno H, Yokota K, Hoshi J, Yasue K, Hayashi M, Uchida I, Aisaka K, Hase Y, Katoh S, Cho H. Ueno H, et al. Among authors: hase y. Bioorg Med Chem Lett. 2005 Jan 3;15(1):185-9. doi: 10.1016/j.bmcl.2004.10.033. Bioorg Med Chem Lett. 2005. PMID: 15582437

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