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Sustained augmentation of cardiac alpha1A-adrenergic drive results in pathological remodeling with contractile dysfunction, progressive fibrosis and reactivation of matricellular protein genes.
Chaulet H, Lin F, Guo J, Owens WA, Michalicek J, Kesteven SH, Guan Z, Prall OW, Mearns BM, Feneley MP, Steinberg SF, Graham RM. Chaulet H, et al. J Mol Cell Cardiol. 2006 Apr;40(4):540-52. doi: 10.1016/j.yjmcc.2006.01.015. Epub 2006 Mar 6. J Mol Cell Cardiol. 2006. PMID: 16516910
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.
Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. Prall OW, et al. Among authors: chaulet h. Cell. 2007 Mar 9;128(5):947-59. doi: 10.1016/j.cell.2007.01.042. Cell. 2007. PMID: 17350578 Free PMC article.