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Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.
Borthwick AD, Davies DE, Ertl PF, Exall AM, Haley TM, Hart GJ, Jackson DL, Parry NR, Patikis A, Trivedi N, Weingarten GG, Woolven JM. Borthwick AD, et al. Among authors: hart gj. J Med Chem. 2003 Oct 9;46(21):4428-49. doi: 10.1021/jm030810w. J Med Chem. 2003. PMID: 14521407
Investigation of the covalent modification of the catalytic triad of human cytomegalovirus protease by pseudo-reversible beta-lactam inhibitors and a peptide chloromethylketone.
Haley TM, Angier SJ, Borthwick AD, Montgomery DS, Purvis IJ, Smart DH, Bessant C, Van Wely C, Hart GJ. Haley TM, et al. Among authors: hart gj. J Mass Spectrom. 1998 Dec;33(12):1246-55. doi: 10.1002/(SICI)1096-9888(199812)33:12<1246::AID-JMS743>3.0.CO;2-E. J Mass Spectrom. 1998. PMID: 9875526
Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.
Macdonald SJ, Cameron R, Demaine DA, Fenton RJ, Foster G, Gower D, Hamblin JN, Hamilton S, Hart GJ, Hill AP, Inglis GG, Jin B, Jones HT, McConnell DB, McKimm-Breschkin J, Mills G, Nguyen V, Owens IJ, Parry N, Shanahan SE, Smith D, Watson KG, Wu WY, Tucker SP. Macdonald SJ, et al. Among authors: hart gj. J Med Chem. 2005 Apr 21;48(8):2964-71. doi: 10.1021/jm040891b. J Med Chem. 2005. PMID: 15828835
Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen.
Macdonald SJ, Watson KG, Cameron R, Chalmers DK, Demaine DA, Fenton RJ, Gower D, Hamblin JN, Hamilton S, Hart GJ, Inglis GG, Jin B, Jones HT, McConnell DB, Mason AM, Nguyen V, Owens IJ, Parry N, Reece PA, Shanahan SE, Smith D, Wu WY, Tucker SP. Macdonald SJ, et al. Among authors: hart gj. Antimicrob Agents Chemother. 2004 Dec;48(12):4542-9. doi: 10.1128/AAC.48.12.4542-4549.2004. Antimicrob Agents Chemother. 2004. PMID: 15561823 Free PMC article.
Predictors of starting and stopping chemsex in men who have sex with men in England: findings from the AURAH2 prospective study.
Hammond R, Cambiano V, Lampe FC, Asboe D, Clarke A, Gilson R, Hart GJ, Miltz AR, Nwokolo N, Johnson AM, Phillips AN, Speakman A, Whitlock G, Rodger A, Sewell J. Hammond R, et al. Among authors: hart gj. Sex Transm Infect. 2023 Nov;99(7):474-481. doi: 10.1136/sextrans-2023-055774. Epub 2023 Jun 15. Sex Transm Infect. 2023. PMID: 37321843 Free PMC article.
Opposing associations of depression with sexual behaviour: implications for epidemiological investigation among gay, bisexual and other men who have sex with men.
Miltz AR, Rodger AJ, Phillips AN, Sewell J, Edwards S, Allan S, Sherr L, Johnson AM, Burman WJ, Lampe FC; ASTRA and AURAH Study Groups. Miltz AR, et al. Sex Transm Infect. 2021 Dec;97(8):613-618. doi: 10.1136/sextrans-2020-054634. Epub 2021 Jan 11. Sex Transm Infect. 2021. PMID: 33431606 Free PMC article.
Associations of depression and anxiety symptoms with sexual behaviour in women and heterosexual men attending sexual health clinics: a cross-sectional study.
Coyle RM, Lampe FC, Miltz AR, Sewell J, Anderson J FRCP, Apea V, Collins S, Dhairyawan R, Johnson AM, Lascar M, Mann S, O'Connell R, Sherr L, Speakman A, Tang A, Phillips AN, Rodger A; AURAH Study Group. Coyle RM, et al. Sex Transm Infect. 2019 Jun;95(4):254-261. doi: 10.1136/sextrans-2018-053689. Epub 2019 Feb 27. Sex Transm Infect. 2019. PMID: 30814165 Free PMC article.
122 results