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Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Campiani G, Butini S, Gemma S, Nacci V, Fattorusso C, Catalanotti B, Giorgi G, Cagnotto A, Goegan M, Mennini T, Minetti P, Di Cesare MA, Mastroianni D, Scafetta N, Galletti B, Stasi MA, Castorina M, Pacifici L, Ghirardi O, Tinti O, Carminati P. Campiani G, et al. Among authors: ghirardi o. J Med Chem. 2002 Jan 17;45(2):344-59. doi: 10.1021/jm010982y. J Med Chem. 2002. PMID: 11784139
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.
Campiani G, Butini S, Fattorusso C, Catalanotti B, Gemma S, Nacci V, Morelli E, Cagnotto A, Mereghetti I, Mennini T, Carli M, Minetti P, Di Cesare MA, Mastroianni D, Scafetta N, Galletti B, Stasi MA, Castorina M, Pacifici L, Vertechy M, Di Serio S, Ghirardi O, Tinti O, Carminati P. Campiani G, et al. Among authors: ghirardi o. J Med Chem. 2004 Jan 1;47(1):143-57. doi: 10.1021/jm0309811. J Med Chem. 2004. PMID: 14695828
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.
Campiani G, Butini S, Fattorusso C, Trotta F, Gemma S, Catalanotti B, Nacci V, Fiorini I, Cagnotto A, Mereghetti I, Mennini T, Minetti P, Di Cesare MA, Stasi MA, Di Serio S, Ghirardi O, Tinti O, Carminati P. Campiani G, et al. Among authors: ghirardi o. J Med Chem. 2005 Mar 24;48(6):1705-8. doi: 10.1021/jm049629t. J Med Chem. 2005. PMID: 15771414
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Minetti P, Tinti MO, Carminati P, Castorina M, Di Cesare MA, Di Serio S, Gallo G, Ghirardi O, Giorgi F, Giorgi L, Piersanti G, Bartoccini F, Tarzia G. Minetti P, et al. Among authors: ghirardi o. J Med Chem. 2005 Nov 3;48(22):6887-96. doi: 10.1021/jm058018d. J Med Chem. 2005. PMID: 16250647
ST2472: a new potential antipsychotic with very low liability to induce side-effects.
Stasi MA, Di Serio S, Vertechy M, Schiavone A, Ghirardi O, Minetti P, Campiani G, Borsini F, Carminati P. Stasi MA, et al. Among authors: ghirardi o. Int J Neuropsychopharmacol. 2008 May;11(3):309-19. doi: 10.1017/S146114570700805X. Epub 2007 Oct 10. Int J Neuropsychopharmacol. 2008. PMID: 17925059 Free article.
ST 1535: a preferential A2A adenosine receptor antagonist.
Stasi MA, Borsini F, Varani K, Vincenzi F, Di Cesare MA, Minetti P, Ghirardi O, Carminati P. Stasi MA, et al. Among authors: ghirardi o. Int J Neuropsychopharmacol. 2006 Oct;9(5):575-84. doi: 10.1017/S1461145705006188. Epub 2005 Nov 23. Int J Neuropsychopharmacol. 2006. PMID: 16867213 Free article.
Olanzapine (LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine), but not the novel atypical antipsychotic ST2472 (9-piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), chronic administration induces weight gain, hyperphagia, and metabolic dysregulation in mice.
Coccurello R, Caprioli A, Conti R, Ghirardi O, Borsini F, Carminati P, Moles A. Coccurello R, et al. Among authors: ghirardi o. J Pharmacol Exp Ther. 2008 Sep;326(3):905-11. doi: 10.1124/jpet.108.137240. Epub 2008 Jun 20. J Pharmacol Exp Ther. 2008. PMID: 18567835
53 results