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Page 1
Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.
Rudolph MJ, Illig CR, Subasinghe NL, Wilson KJ, Hoffman JB, Randle T, Green D, Molloy CJ, Soll RM, Lewandowski F, Zhang M, Bone R, Spurlino JC, Deckman IC, Manthey C, Sharp C, Maguire D, Grasberger BL, DesJarlais RL, Zhou Z. Rudolph MJ, et al. Among authors: molloy cj. Bioorg Med Chem Lett. 2002 Feb 11;12(3):491-5. doi: 10.1016/s0960-894x(01)00787-9. Bioorg Med Chem Lett. 2002. PMID: 11814826
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.
Grasberger BL, Lu T, Schubert C, Parks DJ, Carver TE, Koblish HK, Cummings MD, LaFrance LV, Milkiewicz KL, Calvo RR, Maguire D, Lattanze J, Franks CF, Zhao S, Ramachandren K, Bylebyl GR, Zhang M, Manthey CL, Petrella EC, Pantoliano MW, Deckman IC, Spurlino JC, Maroney AC, Tomczuk BE, Molloy CJ, Bone RF. Grasberger BL, et al. Among authors: molloy cj. J Med Chem. 2005 Feb 24;48(4):909-12. doi: 10.1021/jm049137g. J Med Chem. 2005. PMID: 15715460
A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s.
Subasinghe NL, Travins JM, Ali F, Huang H, Ballentine SK, Marugán JJ, Khalil E, Hufnagel HR, Bone RF, DesJarlais RL, Crysler CS, Ninan N, Cummings MD, Molloy CJ, Tomczuk BE. Subasinghe NL, et al. Among authors: molloy cj. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2200-4. doi: 10.1016/j.bmcl.2006.01.036. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16460935
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.
Travins JM, Ali F, Huang H, Ballentine SK, Khalil E, Hufnagel HR, Pan W, Gushue J, Leonard K, Bone RF, Soll RM, DesJarlais RL, Crysler CS, Ninan N, Kirkpatrick J, Cummings MD, Huebert N, Molloy CJ, Gaul M, Tomczuk BE, Subasinghe NL. Travins JM, et al. Among authors: molloy cj. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1603-6. doi: 10.1016/j.bmcl.2008.01.064. Epub 2008 Jan 19. Bioorg Med Chem Lett. 2008. PMID: 18242991
Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.
Wilson KJ, Illig CR, Subasinghe N, Hoffman JB, Rudolph MJ, Soll R, Molloy CJ, Bone R, Green D, Randall T, Zhang M, Lewandowski FA, Zhou Z, Sharp C, Maguire D, Grasberger B, DesJarlais RL, Spurlino J. Wilson KJ, et al. Among authors: molloy cj. Bioorg Med Chem Lett. 2001 Apr 9;11(7):915-8. doi: 10.1016/s0960-894x(01)00102-0. Bioorg Med Chem Lett. 2001. PMID: 11294390
Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.
Subasinghe NL, Illig C, Hoffman J, Rudolph MJ, Wilson KJ, Soll R, Randle T, Green D, Lewandowski F, Zhang M, Bone R, Spurlino J, DesJarlais R, Deckman I, Molloy CJ, Manthey C, Zhou Z, Sharp C, Maguire D, Crysler C, Grasberger B. Subasinghe NL, et al. Among authors: molloy cj. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1379-82. doi: 10.1016/s0960-894x(01)00247-5. Bioorg Med Chem Lett. 2001. PMID: 11378359
Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors.
Wall MJ, Chen J, Meegalla S, Ballentine SK, Wilson KJ, DesJarlais RL, Schubert C, Chaikin MA, Crysler C, Petrounia IP, Donatelli RR, Yurkow EJ, Boczon L, Mazzulla M, Player MR, Patch RJ, Manthey CL, Molloy C, Tomczuk B, Illig CR. Wall MJ, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2097-102. doi: 10.1016/j.bmcl.2008.01.088. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18289848
Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor.
Winters MP, Crysler C, Subasinghe N, Ryan D, Leong L, Zhao S, Donatelli R, Yurkow E, Mazzulla M, Boczon L, Manthey CL, Molloy C, Raymond H, Murray L, McAlonan L, Tomczuk B. Winters MP, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1926-30. doi: 10.1016/j.bmcl.2008.01.127. Epub 2008 Feb 7. Bioorg Med Chem Lett. 2008. PMID: 18308567
Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.
Illig CR, Chen J, Wall MJ, Wilson KJ, Ballentine SK, Rudolph MJ, DesJarlais RL, Chen Y, Schubert C, Petrounia I, Crysler CS, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Meegalla SK. Illig CR, et al. Among authors: molloy cj. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8. doi: 10.1016/j.bmcl.2008.01.059. Epub 2008 Jan 19. Bioorg Med Chem Lett. 2008. PMID: 18242992
Structure-based optimization of a potent class of arylamide FMS inhibitors.
Meegalla SK, Wall MJ, Chen J, Wilson KJ, Ballentine SK, Desjarlais RL, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Illig CR. Meegalla SK, et al. Among authors: molloy cj. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3632-7. doi: 10.1016/j.bmcl.2008.04.059. Epub 2008 Apr 26. Bioorg Med Chem Lett. 2008. PMID: 18495479
95 results