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The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J, Whisstock JC. Law RH, et al. Among authors: irving ja. J Biol Chem. 2005 Jun 10;280(23):22356-64. doi: 10.1074/jbc.M412043200. Epub 2005 Mar 10. J Biol Chem. 2005. PMID: 15760906 Free article.
X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
McGowan S, Buckle AM, Irving JA, Ong PC, Bashtannyk-Puhalovich TA, Kan WT, Henderson KN, Bulynko YA, Popova EY, Smith AI, Bottomley SP, Rossjohn J, Grigoryev SA, Pike RN, Whisstock JC. McGowan S, et al. Among authors: irving ja. EMBO J. 2006 Jul 12;25(13):3144-55. doi: 10.1038/sj.emboj.7601201. Epub 2006 Jun 29. EMBO J. 2006. PMID: 16810322 Free PMC article.
DNA accelerates the inhibition of human cathepsin V by serpins.
Ong PC, McGowan S, Pearce MC, Irving JA, Kan WT, Grigoryev SA, Turk B, Silverman GA, Brix K, Bottomley SP, Whisstock JC, Pike RN. Ong PC, et al. Among authors: irving ja. J Biol Chem. 2007 Dec 21;282(51):36980-6. doi: 10.1074/jbc.M706991200. Epub 2007 Oct 8. J Biol Chem. 2007. PMID: 17923478 Free article.
Conformational change in the chromatin remodelling protein MENT.
Ong PC, Golding SJ, Pearce MC, Irving JA, Grigoryev SA, Pike D, Langendorf CG, Bashtannyk-Puhalovich TA, Bottomley SP, Whisstock JC, Pike RN, McGowan S. Ong PC, et al. Among authors: irving ja. PLoS One. 2009;4(3):e4727. doi: 10.1371/journal.pone.0004727. Epub 2009 Mar 6. PLoS One. 2009. PMID: 19266095 Free PMC article.
Serpins: finely balanced conformational traps.
Pike RN, Bottomley SP, Irving JA, Bird PI, Whisstock JC. Pike RN, et al. Among authors: irving ja. IUBMB Life. 2002 Jul;54(1):1-7. doi: 10.1080/15216540213825. IUBMB Life. 2002. PMID: 12387568 Free article. Review.
Serpins in prokaryotes.
Irving JA, Steenbakkers PJ, Lesk AM, Op den Camp HJ, Pike RN, Whisstock JC. Irving JA, et al. Mol Biol Evol. 2002 Nov;19(11):1881-90. doi: 10.1093/oxfordjournals.molbev.a004012. Mol Biol Evol. 2002. PMID: 12411597
188 results