Silva MF - Search Results

1

Complete beta-oxidation of valproate: cleavage of 3-oxovalproyl-CoA by a mitochondrial 3-oxoacyl-CoA thiolase.

Silva MF, Ruiter JP, Overmars H, Bootsma AH, van Gennip AH, Jakobs C, Duran M, Tavares de Almeida I, Wanders RJ. Silva MF, et al. Biochem J. 2002 Mar 15;362(Pt 3):755-60. doi: 10.1042/0264-6021:3620755. Biochem J. 2002. PMID: 11879205 Free PMC article.

2

Valproyl-dephosphoCoA: a novel metabolite of valproate formed in vitro in rat liver mitochondria.

Silva MF, Ijlst L, Allers P, Jakobs C, Duran M, de Almeida IT, Wanders RJ. Silva MF, et al. Drug Metab Dispos. 2004 Nov;32(11):1304-10. doi: 10.1124/dmd.... Drug Metab Dispos. 2004. PMID: 15483197

3

Synthesis and intramitochondrial levels of valproyl-coenzyme A metabolites.

Silva MF, Ruiter JP, IJlst L, Allers P, ten Brink HJ, Jakobs C, Duran M, Tavares de Almeida I, Wanders RJ. Silva MF, et al. Anal Biochem. 2001 Mar 1;290(1):60-7. doi: 10.1006/abio.2000.4947. Anal Biochem. 2001. PMID: 11180937

4

Valproate induces in vitro accumulation of long-chain fatty acylcarnitines.

Silva MF, Jakobs C, Duran M, de Almeida IT, Wanders RJ. Silva MF, et al. Mol Genet Metab. 2001 Aug;73(4):358-61. doi: 10.1006/mgme.2001.3200. Mol Genet Metab. 2001. PMID: 11509020

5

Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids.

Silva MF, Ruiter JP, IJlst L, Jakobs C, Duran M, de Almeida IT, Wanders RJ. Silva MF, et al. Chem Biol Interact. 2001 Sep 28;137(3):203-12. doi: 10.1016/s0009-2797(01)00234-4. Chem Biol Interact. 2001. PMID: 11566289

6

Characterization of plasma acylcarnitines in patients under valproate monotherapy using ESI-MS/MS.

Silva MF, Selhorst J, Overmars H, van Gennip AH, Maya M, Wanders RJ, de Almeida IT, Duran M. Silva MF, et al. Clin Biochem. 2001 Nov;34(8):635-8. doi: 10.1016/s0009-9120(01)00272-7. Clin Biochem. 2001. PMID: 11849623

7

Studies on the extra-mitochondrial CoA -ester formation of valproic and Delta4 -valproic acids.

Aires CC, Ruiter JP, Luís PB, ten Brink HJ, Ijlst L, de Almeida IT, Duran M, Wanders RJ, Silva MF. Aires CC, et al. Among authors: silva mf. Biochim Biophys Acta. 2007 Apr;1771(4):533-43. doi: 10.1016/j.bbalip.2007.01.010. Epub 2007 Jan 23. Biochim Biophys Acta. 2007. PMID: 17321204

8

Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis.

Aires CC, Ijlst L, Stet F, Prip-Buus C, de Almeida IT, Duran M, Wanders RJ, Silva MF. Aires CC, et al. Among authors: silva mf. Biochem Pharmacol. 2010 Mar 1;79(5):792-9. doi: 10.1016/j.bcp.2009.10.011. Epub 2009 Oct 23. Biochem Pharmacol. 2010. PMID: 19854160

9

New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA.

Aires CC, van Cruchten A, Ijlst L, de Almeida IT, Duran M, Wanders RJ, Silva MF. Aires CC, et al. Among authors: silva mf. J Hepatol. 2011 Aug;55(2):426-34. doi: 10.1016/j.jhep.2010.11.031. Epub 2010 Dec 13. J Hepatol. 2011. PMID: 21147182

10

Role of isovaleryl-CoA dehydrogenase and short branched-chain acyl-CoA dehydrogenase in the metabolism of valproic acid: implications for the branched-chain amino acid oxidation pathway.

Luís PB, Ruiter JP, Ijlst L, Tavares de Almeida I, Duran M, Mohsen AW, Vockley J, Wanders RJ, Silva MF. Luís PB, et al. Among authors: silva mf. Drug Metab Dispos. 2011 Jul;39(7):1155-60. doi: 10.1124/dmd.110.037606. Epub 2011 Mar 23. Drug Metab Dispos. 2011. PMID: 21430231 Free PMC article.

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