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Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, Barit D, Schwarz T, Geis C, Kraft P, Barthel K, Schuhmann MK, Herrmann AM, Meuth SG, Stoll G, Meurer S, Schrewe A, Becker L, Gailus-Durner V, Fuchs H, Klopstock T, de Angelis MH, Jandeleit-Dahm K, Shah AM, Weissmann N, Schmidt HH. Kleinschnitz C, et al. PLoS Biol. 2010 Sep 21;8(9):e1000479. doi: 10.1371/journal.pbio.1000479. PLoS Biol. 2010. PMID: 20877715 Free PMC article.
NOX4 is an early initiator of neuropathic pain.
Geis C, Geuss E, Sommer C, Schmidt HH, Kleinschnitz C. Geis C, et al. Among authors: kleinschnitz c. Exp Neurol. 2017 Feb;288:94-103. doi: 10.1016/j.expneurol.2016.11.008. Epub 2016 Nov 14. Exp Neurol. 2017. PMID: 27856286
NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.
Casas AI, Geuss E, Kleikers PWM, Mencl S, Herrmann AM, Buendia I, Egea J, Meuth SG, Lopez MG, Kleinschnitz C, Schmidt HHHW. Casas AI, et al. Among authors: kleinschnitz c. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12315-12320. doi: 10.1073/pnas.1705034114. Epub 2017 Oct 31. Proc Natl Acad Sci U S A. 2017. PMID: 29087944 Free PMC article.
A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection.
Langhauser F, Casas AI, Dao VT, Guney E, Menche J, Geuss E, Kleikers PWM, López MG, Barabási AL, Kleinschnitz C, Schmidt HHHW. Langhauser F, et al. Among authors: kleinschnitz c. NPJ Syst Biol Appl. 2018 Feb 5;4:8. doi: 10.1038/s41540-017-0039-7. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29423274 Free PMC article.
VAS2870 is a pan-NADPH oxidase inhibitor.
Wingler K, Altenhoefer SA, Kleikers PW, Radermacher KA, Kleinschnitz C, Schmidt HH. Wingler K, et al. Among authors: kleinschnitz c. Cell Mol Life Sci. 2012 Sep;69(18):3159-60. doi: 10.1007/s00018-012-1107-1. Epub 2012 Aug 9. Cell Mol Life Sci. 2012. PMID: 22875281 Free PMC article. No abstract available.
510 results