MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.
Zhang Z, Wang H, Li M, Agrawal S, Chen X, Zhang R.
Zhang Z, et al. Among authors: wang h.
J Biol Chem. 2004 Apr 16;279(16):16000-6. doi: 10.1074/jbc.M312264200. Epub 2004 Feb 3.
J Biol Chem. 2004.
PMID: 14761977
Free article.
We have previously reported that antisense MDM2 inhibitors have significant anti-tumor activity in multiple human cancer models with various p53 statuses (Zhang, Z., Li, M., Wang, H., Agrawal, S., and Zhang, R. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11636-11641 …
We have previously reported that antisense MDM2 inhibitors have significant anti-tumor activity in multiple human cancer models with various …