Fischer MJ - Search Results

1

Replacement of the intervening amino acid sequence of a Syk-binding diphosphopeptide by a nonpeptide spacer with preservation of high affinity.

Dekker FJ, de Mol NJ, van Ameijde J, Fischer MJ, Ruijtenbeek R, Redegeld FA, Liskamp RM. Dekker FJ, et al. Among authors: fischer mj. Chembiochem. 2002 Mar 1;3(2-3):238-42. doi: 10.1002/1439-7633(20020301)3:2/3<238::AID-CBIC238>3.0.CO;2-W. Chembiochem. 2002. PMID: 11921404 No abstract available.

2

Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand.

Dekker FJ, de Mol NJ, Fischer MJ, Liskamp RM. Dekker FJ, et al. Among authors: fischer mj. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1241-4. doi: 10.1016/s0960-894x(03)00117-3. Bioorg Med Chem Lett. 2003. PMID: 12657254

3

Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2.

de Mol NJ, Catalina MI, Dekker FJ, Fischer MJ, Heck AJ, Liskamp RM. de Mol NJ, et al. Among authors: fischer mj. Chembiochem. 2005 Dec;6(12):2261-70. doi: 10.1002/cbic.200500141. Chembiochem. 2005. PMID: 16252296

4

Peptoid - peptide hybrids that bind Syk SH2 domains involved in signal transduction.

Ruijtenbeek R, Kruijtzer JA, van de Wiel W, Fischer MJ, Flück M, Redegeld FA, Liskamp RM, Nijkamp FP. Ruijtenbeek R, et al. Among authors: fischer mj. Chembiochem. 2001 Mar 2;2(3):171-9. doi: 10.1002/1439-7633(20010302)2:3<171::AID-CBIC171>3.0.CO;2-B. Chembiochem. 2001. PMID: 11828442

5

Experimental and calculated shift in pK(a) upon binding of phosphotyrosine peptide to the SH2 domain of p56(lck).

de Mol NJ, Gillies MB, Fischer MJ. de Mol NJ, et al. Among authors: fischer mj. Bioorg Med Chem. 2002 May;10(5):1477-82. doi: 10.1016/s0968-0896(01)00407-2. Bioorg Med Chem. 2002. PMID: 11886810

6

Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing metathesis and phosphorylation.

Dekker FJ, de Mol NJ, Fischer MJ, Kemmink J, Liskamp RM. Dekker FJ, et al. Among authors: fischer mj. Org Biomol Chem. 2003 Oct 7;1(19):3297-303. doi: 10.1039/b306681a. Org Biomol Chem. 2003. PMID: 14584793

7

Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain.

de Mol NJ, Catalina MI, Fischer MJ, Broutin I, Maier CS, Heck AJ. de Mol NJ, et al. Among authors: fischer mj. Biochim Biophys Acta. 2004 Jul 1;1700(1):53-64. doi: 10.1016/j.bbapap.2004.03.016. Biochim Biophys Acta. 2004. PMID: 15210125

8

Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.

de Mol NJ, Dekker FJ, Broutin I, Fischer MJ, Liskamp RM. de Mol NJ, et al. Among authors: fischer mj. J Med Chem. 2005 Feb 10;48(3):753-63. doi: 10.1021/jm049359e. J Med Chem. 2005. PMID: 15689159

9

Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.

Catalina MI, Fischer MJ, Dekker FJ, Liskamp RM, Heck AJ. Catalina MI, et al. Among authors: fischer mj. J Am Soc Mass Spectrom. 2005 Jul;16(7):1039-51. doi: 10.1016/j.jasms.2005.02.011. J Am Soc Mass Spectrom. 2005. PMID: 15914019 Free article.

10

Surface plasmon resonance: a general introduction.

de Mol NJ, Fischer MJ. de Mol NJ, et al. Among authors: fischer mj. Methods Mol Biol. 2010;627:1-14. doi: 10.1007/978-1-60761-670-2_1. Methods Mol Biol. 2010. PMID: 20217611

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