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Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation.
Quaglia W, Santoni G, Pigini M, Piergentili A, Gentili F, Buccioni M, Mosca M, Lucciarini R, Amantini C, Nabissi MI, Ballarini P, Poggesi E, Leonardi A, Giannella M. Quaglia W, et al. Among authors: poggesi e. J Med Chem. 2005 Dec 1;48(24):7750-63. doi: 10.1021/jm0580398. J Med Chem. 2005. PMID: 16302814
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel alpha1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents.
Quaglia W, Piergentili A, Del Bello F, Farande Y, Giannella M, Pigini M, Rafaiani G, Carrieri A, Amantini C, Lucciarini R, Santoni G, Poggesi E, Leonardi A. Quaglia W, et al. Among authors: poggesi e. J Med Chem. 2008 Oct 23;51(20):6359-70. doi: 10.1021/jm800461k. Epub 2008 Sep 26. J Med Chem. 2008. PMID: 18817363
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues.
Sagratini G, Angeli P, Buccioni M, Gulini U, Marucci G, Melchiorre C, Poggesi E, Giardinà D. Sagratini G, et al. Among authors: poggesi e. Eur J Med Chem. 2010 Dec;45(12):5800-7. doi: 10.1016/j.ejmech.2010.09.042. Epub 2010 Sep 25. Eur J Med Chem. 2010. PMID: 20934789
Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives in α1-adrenergic and 5-HT1A receptor binding sites recognition.
Bonifazi A, Piergentili A, Del Bello F, Farande Y, Giannella M, Pigini M, Amantini C, Nabissi M, Farfariello V, Santoni G, Poggesi E, Leonardi A, Menegon S, Quaglia W. Bonifazi A, et al. Among authors: poggesi e. J Med Chem. 2013 Jan 24;56(2):584-8. doi: 10.1021/jm301525w. Epub 2013 Jan 8. J Med Chem. 2013. PMID: 23252794
Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists of α1-adrenoceptor.
Silva RO, de Oliveira AS, Nunes Lemes LF, de Camargo Nascente L, Coelho do Nascimento Nogueira P, Silveira ER, Brand GD, Vistoli G, Cilia A, Poggesi E, Buccioni M, Marucci G, Bolognesi ML, Romeiro LAS. Silva RO, et al. Among authors: poggesi e. Eur J Med Chem. 2016 Oct 21;122:601-610. doi: 10.1016/j.ejmech.2016.06.052. Epub 2016 Jun 30. Eur J Med Chem. 2016. PMID: 27448917
52 results