Roth BL - Search Results

1

Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.

Runyon SP, Peddi S, Savage JE, Roth BL, Glennon RA, Westkaemper RB. Runyon SP, et al. Among authors: roth bl. J Med Chem. 2002 Apr 11;45(8):1656-64. doi: 10.1021/jm010354g. J Med Chem. 2002. PMID: 11931619

2

A structure-affinity study of the binding of 4-substituted analogues of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors.

Seggel MR, Yousif MY, Lyon RA, Titeler M, Roth BL, Suba EA, Glennon RA. Seggel MR, et al. Among authors: roth bl. J Med Chem. 1990 Mar;33(3):1032-6. doi: 10.1021/jm00165a023. J Med Chem. 1990. PMID: 2308135

3

Differential ergoline and ergopeptine binding to 5-hydroxytryptamine2A receptors: ergolines require an aromatic residue at position 340 for high affinity binding.

Choudhary MS, Sachs N, Uluer A, Glennon RA, Westkaemper RB, Roth BL. Choudhary MS, et al. Among authors: roth bl. Mol Pharmacol. 1995 Mar;47(3):450-7. Mol Pharmacol. 1995. PMID: 7700242

4

1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist.

Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF. Nichols DE, et al. Among authors: roth bl. J Med Chem. 1994 Dec 9;37(25):4346-51. doi: 10.1021/jm00051a011. J Med Chem. 1994. PMID: 7996545

5

9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist.

Westkaemper RB, Runyon SP, Bondarev ML, Savage JE, Roth BL, Glennon RA. Westkaemper RB, et al. Among authors: roth bl. Eur J Pharmacol. 1999 Sep 3;380(1):R5-7. doi: 10.1016/s0014-2999(99)00525-7. Eur J Pharmacol. 1999. PMID: 10513561

6

2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.

Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, McBride A, Rauser L, Hufeisen S, Lee DK. Glennon RA, et al. Among authors: roth bl. J Med Chem. 2000 Mar 9;43(5):1011-8. doi: 10.1021/jm990550b. J Med Chem. 2000. PMID: 10715164

7

A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism.

Kristiansen K, Kroeze WK, Willins DL, Gelber EI, Savage JE, Glennon RA, Roth BL. Kristiansen K, et al. Among authors: roth bl. J Pharmacol Exp Ther. 2000 Jun;293(3):735-46. J Pharmacol Exp Ther. 2000. PMID: 10869371

8

N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.

Tsai Y, Dukat M, Slassi A, MacLean N, Demchyshyn L, Savage JE, Roth BL, Hufesein S, Lee M, Glennon RA. Tsai Y, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2295-9. doi: 10.1016/s0960-894x(00)00453-4. Bioorg Med Chem Lett. 2000. PMID: 11055342

9

Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.

Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL. Rothman RB, et al. Among authors: roth bl. Circulation. 2000 Dec 5;102(23):2836-41. doi: 10.1161/01.cir.102.23.2836. Circulation. 2000. PMID: 11104741

10

Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.

Westkaemper RB, Runyon SP, Savage JE, Roth BL, Glennon RA. Westkaemper RB, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. doi: 10.1016/s0960-894x(01)00010-5. Bioorg Med Chem Lett. 2001. PMID: 11229772

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