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Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines.
Heikkilä P, Teronen O, Moilanen M, Konttinen YT, Hanemaaijer R, Laitinen M, Maisi P, van der Pluijm G, Bartlett JD, Salo T, Sorsa T. Heikkilä P, et al. Among authors: konttinen yt. Anticancer Drugs. 2002 Mar;13(3):245-54. doi: 10.1097/00001813-200203000-00006. Anticancer Drugs. 2002. PMID: 11984068
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.
Heikkilä P, Teronen O, Hirn MY, Sorsa T, Tervahartiala T, Salo T, Konttinen YT, Halttunen T, Moilanen M, Hanemaaijer R, Laitinen M. Heikkilä P, et al. Among authors: konttinen yt. J Surg Res. 2003 May 1;111(1):45-52. doi: 10.1016/s0022-4804(03)00086-6. J Surg Res. 2003. PMID: 12842447
MMP inhibition and downregulation by bisphosphonates.
Teronen O, Heikkilä P, Konttinen YT, Laitinen M, Salo T, Hanemaaijer R, Teronen A, Maisi P, Sorsa T. Teronen O, et al. Among authors: konttinen yt. Ann N Y Acad Sci. 1999 Jun 30;878:453-65. doi: 10.1111/j.1749-6632.1999.tb07702.x. Ann N Y Acad Sci. 1999. PMID: 10415748
Activation of type IV procollagenases by human tumor-associated trypsin-2.
Sorsa T, Salo T, Koivunen E, Tyynelä J, Konttinen YT, Bergmann U, Tuuttila A, Niemi E, Teronen O, Heikkilä P, Tschesche H, Leinonen J, Osman S, Stenman UH. Sorsa T, et al. Among authors: konttinen yt. J Biol Chem. 1997 Aug 22;272(34):21067-74. doi: 10.1074/jbc.272.34.21067. J Biol Chem. 1997. PMID: 9261109 Free article.
737 results