Graham IR - Search Results

1

Gene repair and mutagenesis mediated by chimeric RNA-DNA oligonucleotides: chimeraplasty for gene therapy and conversion of single nucleotide polymorphisms (SNPs).

Graham IR, Dickson G. Graham IR, et al. Biochim Biophys Acta. 2002 May 21;1587(1):1-6. doi: 10.1016/s0925-4439(02)00068-6. Biochim Biophys Acta. 2002. PMID: 12009417 Free article. Review.

2

Oligonucleotide-based gene correction strategies: applications to neuromuscular and cardiovascular diseases.

Graham IR, Beattie SG, Hill VJ, Dickson G. Graham IR, et al. Croat Med J. 2001 Aug;42(4):467-72. Croat Med J. 2001. PMID: 11471201 Free article.

3

Failure to generate atheroprotective apolipoprotein AI phenotypes using synthetic RNA/DNA oligonucleotides (chimeraplasts).

Manzano A, Mohri Z, Sperber G, Ogris M, Graham I, Dickson G, Owen JS. Manzano A, et al. J Gene Med. 2003 Sep;5(9):795-802. doi: 10.1002/jgm.403. J Gene Med. 2003. PMID: 12950070

4

Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE.

Harris JD, Graham IR, Schepelmann S, Stannard AK, Roberts ML, Hodges BL, Hill V, Amalfitano A, Hassall DG, Owen JS, Dickson G. Harris JD, et al. Among authors: graham ir. Hum Mol Genet. 2002 Jan 1;11(1):43-58. doi: 10.1093/hmg/11.1.43. Hum Mol Genet. 2002. PMID: 11772998

5

Stable micro-dystrophin gene transfer using an integrating adeno-retroviral hybrid vector ameliorates the dystrophic pathology in mdx mouse muscle.

Roberts ML, Wells DJ, Graham IR, Fabb SA, Hill VJ, Duisit G, Yuasa K, Takeda S, Cosset FL, Dickson G. Roberts ML, et al. Among authors: graham ir. Hum Mol Genet. 2002 Jul 15;11(15):1719-30. doi: 10.1093/hmg/11.15.1719. Hum Mol Genet. 2002. PMID: 12095914

6

Towards a therapeutic inhibition of dystrophin exon 23 splicing in mdx mouse muscle induced by antisense oligoribonucleotides (splicomers): target sequence optimisation using oligonucleotide arrays.

Graham IR, Hill VJ, Manoharan M, Inamati GB, Dickson G. Graham IR, et al. J Gene Med. 2004 Oct;6(10):1149-58. doi: 10.1002/jgm.603. J Gene Med. 2004. PMID: 15386737

7

Apolipoprotein E delivery by peritoneal implantation of encapsulated recombinant cells improves the hyperlipidaemic profile in apoE-deficient mice.

Tagalakis AD, Diakonov IA, Graham IR, Heald KA, Harris JD, Mulcahy JV, Dickson G, Owen JS. Tagalakis AD, et al. Among authors: graham ir. Biochim Biophys Acta. 2005 Jan 5;1686(3):190-9. doi: 10.1016/j.bbalip.2004.10.001. Biochim Biophys Acta. 2005. PMID: 15629688

8

RNAi-mediated knockdown of dystrophin expression in adult mice does not lead to overt muscular dystrophy pathology.

Ghahramani Seno MM, Graham IR, Athanasopoulos T, Trollet C, Pohlschmidt M, Crompton MR, Dickson G. Ghahramani Seno MM, et al. Among authors: graham ir. Hum Mol Genet. 2008 Sep 1;17(17):2622-32. doi: 10.1093/hmg/ddn162. Epub 2008 May 28. Hum Mol Genet. 2008. PMID: 18511456

9

Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer.

Foster H, Sharp PS, Athanasopoulos T, Trollet C, Graham IR, Foster K, Wells DJ, Dickson G. Foster H, et al. Among authors: graham ir. Mol Ther. 2008 Nov;16(11):1825-32. doi: 10.1038/mt.2008.186. Epub 2008 Sep 2. Mol Ther. 2008. PMID: 18766174 Free article.

10

Adenovirus-based targeting in myoblasts is hampered by nonhomologous vector integration.

Isman O, Roberts ML, Morgan JE, Graham IR, Goldring K, Lawrence-Watt DJ, Lu QL, Dunckley MG, Porter AC, Partridge TA, Dickson G. Isman O, et al. Among authors: graham ir. Hum Gene Ther. 2008 Oct;19(10):1000-8. doi: 10.1089/hum.2008.063. Hum Gene Ther. 2008. PMID: 18788904

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