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Page 1
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.
Ng HP, Buckman BO, Eagen KA, Guilford WJ, Kochanny MJ, Mohan R, Shaw KJ, Wu SC, Lentz D, Liang A, Trinh L, Ho E, Smith D, Subramanyam B, Vergona R, Walters J, White KA, Sullivan ME, Morrissey MM, Phillips GB. Ng HP, et al. Among authors: trinh l. Bioorg Med Chem. 2002 Mar;10(3):657-66. doi: 10.1016/s0968-0896(01)00338-8. Bioorg Med Chem. 2002. PMID: 11814853
Design and synthesis of aminophenol-based factor Xa inhibitors.
Wu S, Guilford WJ, Chou YL, Griedel BD, Liang A, Sakata S, Shaw KJ, Trinh L, Xu W, Zhao Z, Morrissey MM. Wu S, et al. Among authors: trinh l. Bioorg Med Chem Lett. 2002 May 6;12(9):1307-10. doi: 10.1016/s0960-894x(02)00142-7. Bioorg Med Chem Lett. 2002. PMID: 11965377
Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Kirkland TA, Adler M, Bauman JG, Chen M, Haeggström JZ, King B, Kochanny MJ, Liang AM, Mendoza L, Phillips GB, Thunnissen M, Trinh L, Whitlow M, Ye B, Ye H, Parkinson J, Guilford WJ. Kirkland TA, et al. Among authors: trinh l. Bioorg Med Chem. 2008 May 1;16(9):4963-83. doi: 10.1016/j.bmc.2008.03.042. Epub 2008 Mar 20. Bioorg Med Chem. 2008. PMID: 18394906
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Phillips GB, Buckman BO, Davey DD, Eagen KA, Guilford WJ, Hinchman J, Ho E, Koovakkat S, Liang A, Light DR, Mohan R, Ng HP, Post JM, Shaw KJ, Smith D, Subramanyam B, Sullivan ME, Trinh L, Vergona R, Walters J, White K, Whitlow M, Wu S, Xu W, Morrissey MM. Phillips GB, et al. Among authors: trinh l. J Med Chem. 1998 Sep 10;41(19):3557-62. doi: 10.1021/jm980280h. J Med Chem. 1998. PMID: 9733480 No abstract available.
346 results