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Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells.
Cripe TP, Dunphy EJ, Holub AD, Saini A, Vasi NH, Mahller YY, Collins MH, Snyder JD, Krasnykh V, Curiel DT, Wickham TJ, DeGregori J, Bergelson JM, Currier MA. Cripe TP, et al. Among authors: bergelson jm. Cancer Res. 2001 Apr 1;61(7):2953-60. Cancer Res. 2001. PMID: 11306473
Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: role for tethered mucins as barriers to lumenal infection.
Stonebraker JR, Wagner D, Lefensty RW, Burns K, Gendler SJ, Bergelson JM, Boucher RC, O'Neal WK, Pickles RJ. Stonebraker JR, et al. Among authors: bergelson jm. J Virol. 2004 Dec;78(24):13755-68. doi: 10.1128/JVI.78.24.13755-13768.2004. J Virol. 2004. PMID: 15564484 Free PMC article.
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
Kaner RJ, Worgall S, Leopold PL, Stolze E, Milano E, Hidaka C, Ramalingam R, Hackett NR, Singh R, Bergelson J, Finberg R, Falck-Pedersen E, Crystal RG. Kaner RJ, et al. Am J Respir Cell Mol Biol. 1999 Mar;20(3):361-70. doi: 10.1165/ajrcmb.20.3.3398. Am J Respir Cell Mol Biol. 1999. PMID: 10030833
92 results