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Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines.
Heikkilä P, Teronen O, Moilanen M, Konttinen YT, Hanemaaijer R, Laitinen M, Maisi P, van der Pluijm G, Bartlett JD, Salo T, Sorsa T. Heikkilä P, et al. Among authors: moilanen m. Anticancer Drugs. 2002 Mar;13(3):245-54. doi: 10.1097/00001813-200203000-00006. Anticancer Drugs. 2002. PMID: 11984068
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.
Heikkilä P, Teronen O, Hirn MY, Sorsa T, Tervahartiala T, Salo T, Konttinen YT, Halttunen T, Moilanen M, Hanemaaijer R, Laitinen M. Heikkilä P, et al. Among authors: moilanen m. J Surg Res. 2003 May 1;111(1):45-52. doi: 10.1016/s0022-4804(03)00086-6. J Surg Res. 2003. PMID: 12842447
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