Guay D - Search Results

1

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding.

Chauret N, Guay D, Li C, Day S, Silva J, Blouin M, Ducharme Y, Yergey JA, Nicoll-Griffith DA. Chauret N, et al. Among authors: guay d. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2149-52. doi: 10.1016/s0960-894x(02)00349-9. Bioorg Med Chem Lett. 2002. PMID: 12127525

2

Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.

Guay D, Hamel P, Blouin M, Brideau C, Chan CC, Chauret N, Ducharme Y, Huang Z, Girard M, Jones TR, Laliberté F, Masson P, McAuliffe M, Piechuta H, Silva J, Young RN, Girard Y. Guay D, et al. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61. doi: 10.1016/s0960-894x(02)00190-7. Bioorg Med Chem Lett. 2002. PMID: 12031319

3

Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.

Friesen RW, Ducharme Y, Ball RG, Blouin M, Boulet L, Côté B, Frenette R, Girard M, Guay D, Huang Z, Jones TR, Laliberté F, Lynch JJ, Mancini J, Martins E, Masson P, Muise E, Pon DJ, Siegl PK, Styhler A, Tsou NN, Turner MJ, Young RN, Girard Y. Friesen RW, et al. Among authors: guay d. J Med Chem. 2003 Jun 5;46(12):2413-26. doi: 10.1021/jm0204542. J Med Chem. 2003. PMID: 12773045

4

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

Beaulieu C, Guay D, Wang Z, Leblanc Y, Roy P, Dufresne C, Zamboni R, Berthelette C, Day S, Tsou N, Denis D, Greig G, Mathieu MC, O'Neill G. Beaulieu C, et al. Among authors: guay d. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2696-700. doi: 10.1016/j.bmcl.2008.03.015. Epub 2008 Mar 10. Bioorg Med Chem Lett. 2008. PMID: 18359630

5

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.

Gallant M, Aspiotis R, Day S, Dias R, Dubé D, Dubé L, Friesen RW, Girard M, Guay D, Hamel P, Huang Z, Lacombe P, Laliberté S, Lévesque JF, Liu S, Macdonald D, Mancini J, Nicholson DW, Styhler A, Townson K, Waters K, Young RN, Girard Y. Gallant M, et al. Among authors: guay d. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6387-93. doi: 10.1016/j.bmcl.2010.09.087. Epub 2010 Sep 21. Bioorg Med Chem Lett. 2010. PMID: 20933411

6

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

Gallant M, Beaulieu C, Berthelette C, Colucci J, Crackower MA, Dalton C, Denis D, Ducharme Y, Friesen RW, Guay D, Gervais FG, Hamel M, Houle R, Krawczyk CM, Kosjek B, Lau S, Leblanc Y, Lee EE, Levesque JF, Mellon C, Molinaro C, Mullet W, O'Neill GP, O'Shea P, Sawyer N, Sillaots S, Simard D, Slipetz D, Stocco R, Sørensen D, Truong VL, Wong E, Wu J, Zaghdane H, Wang Z. Gallant M, et al. Among authors: guay d. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. doi: 10.1016/j.bmcl.2010.11.015. Epub 2010 Nov 5. Bioorg Med Chem Lett. 2011. PMID: 21106375

7

Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.

Ouimet N, Chan CC, Charleson S, Claveau D, Gordon R, Guay D, Li CS, Ouellet M, Percival DM, Riendeau D, Wong E, Zamboni R, Prasit P. Ouimet N, et al. Among authors: guay d. Bioorg Med Chem Lett. 1999 Jan 18;9(2):151-6. doi: 10.1016/s0960-894x(98)00705-7. Bioorg Med Chem Lett. 1999. PMID: 10021918

8

Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives.

Li CS, Black WC, Chan CC, Ford-Hutchinson AW, Gauthier JY, Gordon R, Guay D, Kargman S, Lau CK, Mancini J, et al. Li CS, et al. Among authors: guay d. J Med Chem. 1995 Dec 8;38(25):4897-905. doi: 10.1021/jm00025a007. J Med Chem. 1995. PMID: 8523403

9

Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor.

Guay D, Boulet L, Friesen RW, Girard M, Hamel P, Huang Z, Laliberté F, Laliberté S, Mancini JA, Muise E, Pon D, Styhler A. Guay D, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5554-8. doi: 10.1016/j.bmcl.2008.09.009. Epub 2008 Sep 6. Bioorg Med Chem Lett. 2008. PMID: 18835163

10

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C.

Guay D, Beaulieu C, Truchon JF, Jagadeeswar Reddy T, Zamboni R, Bayly CI, Methot N, Rubin J, Ethier D, David Percival M. Guay D, et al. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5392-6. doi: 10.1016/j.bmcl.2009.07.114. Epub 2009 Jul 28. Bioorg Med Chem Lett. 2009. PMID: 19665376

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