Matsuda A - Search Results

1

Conformational analysis of the NMDA receptor antagonist (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) designed by a novel conformational restriction method based on the structural feature of cyclopropane ring.

Ono S, Ogawa K, Yamashita K, Yamamoto T, Kazuta Y, Matsuda A, Shuto S. Ono S, et al. Among authors: matsuda a. Chem Pharm Bull (Tokyo). 2002 Jul;50(7):966-8. doi: 10.1248/cpb.50.966. Chem Pharm Bull (Tokyo). 2002. PMID: 12130856 Free article.

2

Development of versatile cis- and trans-dicarbon-substituted chiral cyclopropane units: synthesis of (1S,2R)- and (1R,2R)-2-aminomethyl-1-(1H-imidazol-4-yl)cyclopropanes and their enantiomers as conformationally restricted analogues of histamine.

Kazuta Y, Matsuda A, Shuto S. Kazuta Y, et al. Among authors: matsuda a. J Org Chem. 2002 Mar 8;67(5):1669-77. doi: 10.1021/jo010852x. J Org Chem. 2002. PMID: 11871901

3

Synthesis of (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) derivatives modified at the carbamoyl moiety as a new class of NMDA receptor antagonists.

Kazuta Y, Tsujita R, Ogawa K, Hokonohara T, Yamashita K, Morino K, Matsuda A, Shuto S. Kazuta Y, et al. Among authors: matsuda a. Bioorg Med Chem. 2002 Jun;10(6):1777-91. doi: 10.1016/s0968-0896(02)00030-5. Bioorg Med Chem. 2002. PMID: 11937336

4

Synthesis of derivatives of (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) modified at the 1-aromatic moiety as novel NMDA receptor antagonists: the aromatic group is essential for the activity.

Kazuta Y, Tsujita R, Yamashita K, Uchino S, Kohsaka S, Matsuda A, Shuto S. Kazuta Y, et al. Among authors: matsuda a. Bioorg Med Chem. 2002 Dec;10(12):3829-48. doi: 10.1016/s0968-0896(02)00346-2. Bioorg Med Chem. 2002. PMID: 12413836

5

Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure.

Kazuta Y, Hirano K, Natsume K, Yamada S, Kimura R, Matsumoto S, Furuichi K, Matsuda A, Shuto S. Kazuta Y, et al. Among authors: matsuda a. J Med Chem. 2003 May 8;46(10):1980-8. doi: 10.1021/jm020415q. J Med Chem. 2003. PMID: 12723960

6

Construction of a cis-cyclopropane via reductive radical decarboxylation. Enantioselective synthesis of cis- and trans-1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents.

Yamaguchi K, Kazuta Y, Abe H, Matsuda A, Shuto S. Yamaguchi K, et al. Among authors: matsuda a. J Org Chem. 2003 Nov 28;68(24):9255-62. doi: 10.1021/jo0302206. J Org Chem. 2003. PMID: 14629144

7

Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure.

Watanabe M, Kazuta Y, Hayashi H, Yamada S, Matsuda A, Shuto S. Watanabe M, et al. Among authors: matsuda a. J Med Chem. 2006 Sep 7;49(18):5587-96. doi: 10.1021/jm0603318. J Med Chem. 2006. PMID: 16942032

8

Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: cyclopropane-based conformationally restricted analogs of haloperidol.

Yamaguchi K, Kazuta Y, Hirano K, Yamada S, Matsuda A, Shuto S. Yamaguchi K, et al. Among authors: matsuda a. Bioorg Med Chem. 2008 Oct 1;16(19):8875-81. doi: 10.1016/j.bmc.2008.08.061. Epub 2008 Aug 29. Bioorg Med Chem. 2008. PMID: 18793859

9

Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.

Shuto S, Ono S, Hase Y, Ueno Y, Noguchi T, Yoshii K, Matsuda A. Shuto S, et al. Among authors: matsuda a. J Med Chem. 1996 Nov 22;39(24):4844-52. doi: 10.1021/jm960495w. J Med Chem. 1996. PMID: 8941398

10

Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.

Shuto S, Ono S, Imoto H, Yoshii K, Matsuda A. Shuto S, et al. Among authors: matsuda a. J Med Chem. 1998 Aug 27;41(18):3507-14. doi: 10.1021/jm980238m. J Med Chem. 1998. PMID: 9719604

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