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Transfer of a protein binding epitope to a minimal designed peptide.
Quan C, Skelton NJ, Clark K, Jackson DY, Renz ME, Chiu HH, Keating SM, Beresini MH, Fong S, Artis DR. Quan C, et al. Among authors: beresini mh. Biopolymers. 1998;47(4):265-75. doi: 10.1002/(SICI)1097-0282(1998)47:4<265::AID-BIP2>3.0.CO;2-K. Biopolymers. 1998. PMID: 10036968
Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.
Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters JC Jr, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC. Gadek TR, et al. Among authors: beresini mh. Science. 2002 Feb 8;295(5557):1086-9. doi: 10.1126/science.295.5557.1086. Science. 2002. PMID: 11834839
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.
Camenisch G, Pisabarro MT, Sherman D, Kowalski J, Nagel M, Hass P, Xie MH, Gurney A, Bodary S, Liang XH, Clark K, Beresini M, Ferrara N, Gerber HP. Camenisch G, et al. Among authors: beresini m. J Biol Chem. 2002 May 10;277(19):17281-90. doi: 10.1074/jbc.M109768200. Epub 2002 Feb 27. J Biol Chem. 2002. PMID: 11877390 Free article.
Albumin affinity tags increase peptide half-life in vivo.
Koehler MF, Zobel K, Beresini MH, Caris LD, Combs D, Paasch BD, Lazarus RA. Koehler MF, et al. Among authors: beresini mh. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2883-6. doi: 10.1016/s0960-894x(02)00610-8. Bioorg Med Chem Lett. 2002. PMID: 12270169
A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo.
Olivero AG, Eigenbrot C, Goldsmith R, Robarge K, Artis DR, Flygare J, Rawson T, Sutherlin DP, Kadkhodayan S, Beresini M, Elliott LO, DeGuzman GG, Banner DW, Ultsch M, Marzec U, Hanson SR, Refino C, Bunting S, Kirchhofer D. Olivero AG, et al. J Biol Chem. 2005 Mar 11;280(10):9160-9. doi: 10.1074/jbc.M409068200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632123 Free article.
47 results