Lynch K - Search Results

1

Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats.

Honore P, Kage K, Mikusa J, Watt AT, Johnston JF, Wyatt JR, Faltynek CR, Jarvis MF, Lynch K. Honore P, et al. Among authors: lynch k. Pain. 2002 Sep;99(1-2):11-9. doi: 10.1016/s0304-3959(02)00032-5. Pain. 2002. PMID: 12237180

2

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, Zhu CZ, Chu K, Lee CH, Stewart AO, Polakowski J, Cox BF, Kowaluk E, Williams M, Sullivan J, Faltynek C. Jarvis MF, et al. Among authors: lynch k. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84. doi: 10.1073/pnas.252537299. Epub 2002 Dec 13. Proc Natl Acad Sci U S A. 2002. PMID: 12482951 Free PMC article.

3

Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat.

Kage K, Niforatos W, Zhu CZ, Lynch KJ, Honore P, Jarvis MF. Kage K, et al. Among authors: lynch kj. Exp Brain Res. 2002 Dec;147(4):511-9. doi: 10.1007/s00221-002-1263-x. Epub 2002 Oct 25. Exp Brain Res. 2002. PMID: 12444483

4

Potent desensitization of human P2X3 receptors by diadenosine polyphosphates.

McDonald HA, Chu KL, Bianchi BR, McKenna DG, Briggs CA, Burgard EC, Lynch KJ, Faltynek C, Cartmell J, Jarvis MF. McDonald HA, et al. Eur J Pharmacol. 2002 Jan 25;435(2-3):135-42. doi: 10.1016/s0014-2999(01)01568-0. Eur J Pharmacol. 2002. PMID: 11821019

5

2', 3'-O-(2,4,6,trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor.

Neelands TR, Burgard EC, Uchic ME, McDonald HA, Niforatos W, Faltynek CR, Lynch KJ, Jarvis MF. Neelands TR, et al. Br J Pharmacol. 2003 Sep;140(1):202-10. doi: 10.1038/sj.bjp.0705411. Epub 2003 Jul 29. Br J Pharmacol. 2003. PMID: 12967950 Free PMC article.

6

P2X receptor-mediated ionic currents in dorsal root ganglion neurons.

Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF. Burgard EC, et al. Among authors: lynch kj. J Neurophysiol. 1999 Sep;82(3):1590-8. doi: 10.1152/jn.1999.82.3.1590. J Neurophysiol. 1999. PMID: 10482772 Free article.

7

Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue.

Alexander K, Niforatos W, Bianchi B, Burgard EC, Lynch KJ, Kowaluk EA, Jarvis MF, van Biesen T. Alexander K, et al. Among authors: lynch kj. J Pharmacol Exp Ther. 1999 Dec;291(3):1135-42. J Pharmacol Exp Ther. 1999. PMID: 10565834

8

Molecular and functional characterization of human P2X(2) receptors.

Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF. Lynch KJ, et al. Mol Pharmacol. 1999 Dec;56(6):1171-81. doi: 10.1124/mol.56.6.1171. Mol Pharmacol. 1999. PMID: 10570044

9

Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP).

Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Kage KL, Touma E, Kowaluk EA, Jarvis MF. Burgard EC, et al. Among authors: lynch kj. Mol Pharmacol. 2000 Dec;58(6):1502-10. doi: 10.1124/mol.58.6.1502. Mol Pharmacol. 2000. PMID: 11093790

10

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue.

Jarvis MF, Wismer CT, Schweitzer E, Yu H, van Biesen T, Lynch KJ, Burgard EC, Kowaluk EA. Jarvis MF, et al. Among authors: lynch kj. Br J Pharmacol. 2001 Jan;132(1):259-69. doi: 10.1038/sj.bjp.0703793. Br J Pharmacol. 2001. PMID: 11156585 Free PMC article.

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