Ornstein PL - Search Results

1

Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.

Filla SA, Winter MA, Johnson KW, Bleakman D, Bell MG, Bleisch TJ, Castaño AM, Clemens-Smith A, del Prado M, Dieckman DK, Dominguez E, Escribano A, Ho KH, Hudziak KJ, Katofiasc MA, Martinez-Perez JA, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Phebus LA, Stack DR, Stratford RE, Ornstein PL. Filla SA, et al. Among authors: ornstein pl. J Med Chem. 2002 Sep 26;45(20):4383-6. doi: 10.1021/jm025548q. J Med Chem. 2002. PMID: 12238915

2

Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones.

McQuaid LA, Smith EC, South KK, Mitch CH, Schoepp DD, True RA, Calligaro DO, O'Malley PJ, Lodge D, Ornstein PL. McQuaid LA, et al. Among authors: ornstein pl. J Med Chem. 1992 Sep 4;35(18):3319-24. doi: 10.1021/jm00096a002. J Med Chem. 1992. PMID: 1382133

3

NMDA antagonist activity of (+/-)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid resides with the (-)-2R,4S-isomer.

Ornstein PL, Schoepp DD, Arnold MB, Jones ND, Deeter JB, Lodge D, Leander JD. Ornstein PL, et al. J Med Chem. 1992 Aug 21;35(17):3111-5. doi: 10.1021/jm00095a004. J Med Chem. 1992. PMID: 1387167

4

6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.

Ornstein PL, Schoepp DD, Arnold MB, Augenstein NK, Lodge D, Millar JD, Chambers J, Campbell J, Paschal JW, Zimmerman DM, et al. Ornstein PL, et al. J Med Chem. 1992 Sep 18;35(19):3547-60. doi: 10.1021/jm00097a012. J Med Chem. 1992. PMID: 1404235

5

4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.

Ornstein PL, Schoepp DD, Arnold MB, Leander JD, Lodge D, Paschal JW, Elzey T. Ornstein PL, et al. J Med Chem. 1991 Jan;34(1):90-7. doi: 10.1021/jm00105a016. J Med Chem. 1991. PMID: 1825117

6

Neuroprotectant effects of LY274614, a structurally novel systemically active competitive NMDA receptor antagonist.

Schoepp DD, Ornstein PL, Salhoff CR, Leander JD. Schoepp DD, et al. Among authors: ornstein pl. J Neural Transm Gen Sect. 1991;85(2):131-43. doi: 10.1007/BF01244705. J Neural Transm Gen Sect. 1991. PMID: 1834088

7

Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists.

Ornstein PL, Schaus JM, Chambers JW, Huser DL, Leander JD, Wong DT, Paschal JW, Jones ND, Deeter JB. Ornstein PL, et al. J Med Chem. 1989 Apr;32(4):827-33. doi: 10.1021/jm00124a015. J Med Chem. 1989. PMID: 2539478

8

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.

Ornstein PL, Arnold MB, Augenstein NK, Lodge D, Leander JD, Schoepp DD. Ornstein PL, et al. J Med Chem. 1993 Jul 9;36(14):2046-8. doi: 10.1021/jm00066a016. J Med Chem. 1993. PMID: 8393116 No abstract available.

9

(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.

Ornstein PL, Arnold MB, Allen NK, Leander JD, Tizzano JP, Lodge D, Schoepp DD. Ornstein PL, et al. J Med Chem. 1995 Dec 8;38(25):4885-90. doi: 10.1021/jm00025a005. J Med Chem. 1995. PMID: 8523401

10

In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.

Schoepp DD, Lodge D, Bleakman D, Leander JD, Tizzano JP, Wright RA, Palmer AJ, Salhoff CR, Ornstein PL. Schoepp DD, et al. Among authors: ornstein pl. Neuropharmacology. 1995 Sep;34(9):1159-68. doi: 10.1016/0028-3908(95)00099-r. Neuropharmacology. 1995. PMID: 8532186

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