Sioufi N - Search Results

1

2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.

Prakash TP, Manoharan M, Kawasaki AM, Fraser AS, Lesnik EA, Sioufi N, Leeds JM, Teplova M, Egli M. Prakash TP, et al. Among authors: sioufi n. Biochemistry. 2002 Oct 1;41(39):11642-8. doi: 10.1021/bi020264t. Biochemistry. 2002. PMID: 12269806

2

Improving antisense oligonucleotide binding to human serum albumin: dramatic effect of ibuprofen conjugation.

Manoharan M, Inamati GB, Lesnik EA, Sioufi NB, Freier SM. Manoharan M, et al. Among authors: sioufi nb. Chembiochem. 2002 Dec 2;3(12):1257-60. doi: 10.1002/1439-7633(20021202)3:12<1257::AID-CBIC1257>3.0.CO;2-2. Chembiochem. 2002. PMID: 12465035 No abstract available.

3

Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats.

Geary RS, Watanabe TA, Truong L, Freier S, Lesnik EA, Sioufi NB, Sasmor H, Manoharan M, Levin AA. Geary RS, et al. Among authors: sioufi nb. J Pharmacol Exp Ther. 2001 Mar;296(3):890-7. J Pharmacol Exp Ther. 2001. PMID: 11181921

4

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

Allerson CR, Sioufi N, Jarres R, Prakash TP, Naik N, Berdeja A, Wanders L, Griffey RH, Swayze EE, Bhat B. Allerson CR, et al. Among authors: sioufi n. J Med Chem. 2005 Feb 24;48(4):901-4. doi: 10.1021/jm049167j. J Med Chem. 2005. PMID: 15715458

5

Positional effect of chemical modifications on short interference RNA activity in mammalian cells.

Prakash TP, Allerson CR, Dande P, Vickers TA, Sioufi N, Jarres R, Baker BF, Swayze EE, Griffey RH, Bhat B. Prakash TP, et al. Among authors: sioufi n. J Med Chem. 2005 Jun 30;48(13):4247-53. doi: 10.1021/jm050044o. J Med Chem. 2005. PMID: 15974578

6

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

Dande P, Prakash TP, Sioufi N, Gaus H, Jarres R, Berdeja A, Swayze EE, Griffey RH, Bhat B. Dande P, et al. Among authors: sioufi n. J Med Chem. 2006 Mar 9;49(5):1624-34. doi: 10.1021/jm050822c. J Med Chem. 2006. PMID: 16509579

7

Activity of siRNAs with 2-thio-2'-O-methyluridine modification in mammalian cells.

Prakash TP, Naik N, Sioufi N, Bhat B, Swayze EE. Prakash TP, et al. Among authors: sioufi n. Nucleosides Nucleotides Nucleic Acids. 2009 Oct;28(10):902-10. doi: 10.1080/15257770903316145. Nucleosides Nucleotides Nucleic Acids. 2009. PMID: 20183560

8

A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in normal mice.

Tachas G, Lofthouse S, Wraight CJ, Baker BF, Sioufi NB, Jarres RA, Berdeja A, Rao AM, Kerr LM, d'Aniello EM, Waters MJ. Tachas G, et al. Among authors: sioufi nb. J Endocrinol. 2006 Apr;189(1):147-54. doi: 10.1677/joe.1.06553. J Endocrinol. 2006. PMID: 16614389

9

P2Y13 receptor deficiency favors adipose tissue lipolysis and worsens insulin resistance and fatty liver disease.

Duparc T, Gore E, Combes G, Beuzelin D, Pires Da Silva J, Bouguetoch V, Marquès MA, Velazquez A, Viguerie N, Tavernier G, Arner P, Rydén M, Langin D, Sioufi N, Nasser M, Cabou C, Najib S, Martinez LO. Duparc T, et al. Among authors: sioufi n. JCI Insight. 2024 Mar 12;9(8):e175623. doi: 10.1172/jci.insight.175623. JCI Insight. 2024. PMID: 38470490 Free PMC article.

10

Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-Deficient Mice in a Diet-Dependent Manner, Irrespective of Sex.

Mérian J, Ghezali L, Trenteseaux C, Duparc T, Beuzelin D, Bouguetoch V, Combes G, Sioufi N, Martinez LO, Najib S. Mérian J, et al. Among authors: sioufi n. Cells. 2023 Feb 7;12(4):533. doi: 10.3390/cells12040533. Cells. 2023. PMID: 36831200 Free PMC article.

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