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Page 1
Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.
Watterson SH, Liu C, Dhar TG, Gu HH, Pitts WJ, Barrish JC, Fleener CA, Rouleau K, Sherbina NZ, Hollenbaugh DL, Iwanowicz EJ. Watterson SH, et al. Among authors: rouleau k. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2879-82. doi: 10.1016/s0960-894x(02)00601-7. Bioorg Med Chem Lett. 2002. PMID: 12270168
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.
Dhar TG, Shen Z, Guo J, Liu C, Watterson SH, Gu HH, Pitts WJ, Fleener CA, Rouleau KA, Sherbina NZ, McIntyre KW, Shuster DJ, Witmer MR, Tredup JA, Chen BC, Zhao R, Bednarz MS, Cheney DL, MacMaster JF, Miller LM, Berry KK, Harper TW, Barrish JC, Hollenbaugh DL, Iwanowicz EJ. Dhar TG, et al. Among authors: rouleau ka. J Med Chem. 2002 May 23;45(11):2127-30. doi: 10.1021/jm0105777. J Med Chem. 2002. PMID: 12014950
Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
Pitts WJ, Guo J, Dhar TG, Shen Z, Gu HH, Watterson SH, Bednarz MS, Chen BC, Barrish JC, Bassolino D, Cheney D, Fleener CA, Rouleau KA, Hollenbaugh DL, Iwanowicz EJ. Pitts WJ, et al. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2137-40. doi: 10.1016/s0960-894x(02)00351-7. Bioorg Med Chem Lett. 2002. PMID: 12127522
Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.
Chen P, Norris D, Haslow KD, Murali Dhar TG, Pitts WJ, Watterson SH, Cheney DL, Bassolino DA, Fleener CA, Rouleau KA, Hollenbaugh DL, Townsend RM, Barrish JC, Iwanowicz EJ. Chen P, et al. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1345-8. doi: 10.1016/s0960-894x(03)00107-0. Bioorg Med Chem Lett. 2003. PMID: 12657279
Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Watterson SH, Chen P, Zhao Y, Gu HH, Dhar TG, Xiao Z, Ballentine SK, Shen Z, Fleener CA, Rouleau KA, Obermeier M, Yang Z, McIntyre KW, Shuster DJ, Witmer M, Dambach D, Chao S, Mathur A, Chen BC, Barrish JC, Robl JA, Townsend R, Iwanowicz EJ. Watterson SH, et al. Among authors: rouleau ka. J Med Chem. 2007 Jul 26;50(15):3730-42. doi: 10.1021/jm070299x. Epub 2007 Jun 22. J Med Chem. 2007. PMID: 17585753
79 results