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Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen.
Macdonald SJ, Watson KG, Cameron R, Chalmers DK, Demaine DA, Fenton RJ, Gower D, Hamblin JN, Hamilton S, Hart GJ, Inglis GG, Jin B, Jones HT, McConnell DB, Mason AM, Nguyen V, Owens IJ, Parry N, Reece PA, Shanahan SE, Smith D, Wu WY, Tucker SP. Macdonald SJ, et al. Among authors: gower d. Antimicrob Agents Chemother. 2004 Dec;48(12):4542-9. doi: 10.1128/AAC.48.12.4542-4549.2004. Antimicrob Agents Chemother. 2004. PMID: 15561823 Free PMC article.
Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.
Macdonald SJ, Cameron R, Demaine DA, Fenton RJ, Foster G, Gower D, Hamblin JN, Hamilton S, Hart GJ, Hill AP, Inglis GG, Jin B, Jones HT, McConnell DB, McKimm-Breschkin J, Mills G, Nguyen V, Owens IJ, Parry N, Shanahan SE, Smith D, Watson KG, Wu WY, Tucker SP. Macdonald SJ, et al. Among authors: gower d. J Med Chem. 2005 Apr 21;48(8):2964-71. doi: 10.1021/jm040891b. J Med Chem. 2005. PMID: 15828835
Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients.
Lekova E, Zelek WM, Gower D, Spitzfaden C, Osuch IH, John-Morris E, Stach L, Gormley D, Sanderson A, Bridges A, Wear ER, Petit-Frere S, Burden MN, Priest R, Wattam T, Kitchen SJ, Feeney M, Davis S, Morgan BP, Nichols EM. Lekova E, et al. Among authors: gower d. Front Immunol. 2022 Sep 5;13:968206. doi: 10.3389/fimmu.2022.968206. eCollection 2022. Front Immunol. 2022. PMID: 36148231 Free PMC article.
Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies.
Scott MJ, Jowett A, Orecchia M, Ertl P, Ouro-Gnao L, Ticehurst J, Gower D, Yates J, Poulton K, Harris C, Mullin MJ, Smith KJ, Lewis AP, Barton N, Washburn ML, de Wildt R. Scott MJ, et al. Among authors: gower d. MAbs. 2020 Jan-Dec;12(1):1755069. doi: 10.1080/19420862.2020.1755069. MAbs. 2020. PMID: 32343620 Free PMC article.
285 results