Freidinger RM - Search Results

1

Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity.

Brady SF, Pawluczyk JM, Lumma PK, Feng DM, Wai JM, Jones R, DeFeo-Jones D, Wong BK, Miller-Stein C, Lin JH, Oliff A, Freidinger RM, Garsky VM. Brady SF, et al. Among authors: freidinger rm. J Med Chem. 2002 Oct 10;45(21):4706-15. doi: 10.1021/jm020139f. J Med Chem. 2002. PMID: 12361397

2

A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo.

DeFeo-Jones D, Garsky VM, Wong BK, Feng DM, Bolyar T, Haskell K, Kiefer DM, Leander K, McAvoy E, Lumma P, Wai J, Senderak ET, Motzel SL, Keenan K, Van Zwieten M, Lin JH, Freidinger R, Huff J, Oliff A, Jones RE. DeFeo-Jones D, et al. Nat Med. 2000 Nov;6(11):1248-52. doi: 10.1038/81351. Nat Med. 2000. PMID: 11062536

3

The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy.

Garsky VM, Lumma PK, Feng DM, Wai J, Ramjit HG, Sardana MK, Oliff A, Jones RE, DeFeo-Jones D, Freidinger RM. Garsky VM, et al. Among authors: freidinger rm. J Med Chem. 2001 Nov 22;44(24):4216-24. doi: 10.1021/jm0101996. J Med Chem. 2001. PMID: 11708923

4

A prostate-specific antigen (PSA)-activated vinblastine prodrug selectively kills PSA-secreting cells in vivo.

DeFeo-Jones D, Brady SF, Feng DM, Wong BK, Bolyar T, Haskell K, Kiefer DM, Leander K, McAvoy E, Lumma P, Pawluczyk JM, Wai J, Motzel SL, Keenan K, Van Zwieten M, Lin JH, Garsky VM, Freidinger R, Oliff A, Jones RE. DeFeo-Jones D, et al. Mol Cancer Ther. 2002 May;1(7):451-9. Mol Cancer Ther. 2002. PMID: 12479263

5

2,3-diaminopyridine bradykinin B1 receptor antagonists.

Kuduk SD, Ng C, Feng DM, Wai JM, Chang RS, Harrell CM, Murphy KL, Ransom RW, Reiss D, Ivarsson M, Mason G, Boyce S, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: freidinger rm. J Med Chem. 2004 Dec 16;47(26):6439-42. doi: 10.1021/jm049394l. J Med Chem. 2004. PMID: 15588075

6

2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists.

Feng DM, Wai JM, Kuduk SD, Ng C, Murphy KL, Ransom RW, Reiss D, Chang RS, Harrell CM, MacNeil T, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG. Feng DM, et al. Among authors: freidinger rm. Bioorg Med Chem Lett. 2005 May 2;15(9):2385-8. doi: 10.1016/j.bmcl.2005.02.077. Bioorg Med Chem Lett. 2005. PMID: 15837330

7

Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications.

Freidinger RM, Williams PD, Tung RD, Bock MG, Pettibone DJ, Clineschmidt BV, DiPardo RM, Erb JM, Garsky VM, Gould NP, et al. Freidinger RM, et al. J Med Chem. 1990 Jul;33(7):1843-5. doi: 10.1021/jm00169a001. J Med Chem. 1990. PMID: 2163451 No abstract available.

8

1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist.

Williams PD, Clineschmidt BV, Erb JM, Freidinger RM, Guidotti MT, Lis EV, Pawluczyk JM, Pettibone DJ, Reiss DR, Veber DF, et al. Williams PD, et al. Among authors: freidinger rm. J Med Chem. 1995 Nov 10;38(23):4634-6. doi: 10.1021/jm00023a002. J Med Chem. 1995. PMID: 7473590 No abstract available.

9

Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation.

Williams PD, Ball RG, Clineschmidt BV, Culberson JC, Erb JM, Freidinger RM, Pawluczyk JM, Perlow DS, Pettibone DJ, Veber DF. Williams PD, et al. Among authors: freidinger rm. Bioorg Med Chem. 1994 Sep;2(9):971-85. doi: 10.1016/s0968-0896(00)82046-5. Bioorg Med Chem. 1994. PMID: 7712132

10

Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus.

Kuo MS, Bock MG, Freidinger RM, Guidotti MT, Lis EV, Pawluczyk JM, Perlow DS, Pettibone DJ, Quigley AG, Reiss DR, Williams PD, Woyden CJ. Kuo MS, et al. Among authors: freidinger rm. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3081-6. doi: 10.1016/S0960-894X(98)00568-X. Bioorg Med Chem Lett. 1998. PMID: 9873680

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