Spooren W - Search Results

1

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article.

Kuhn R, Pagano A, Stoehr N, Vranesic I, Flor PJ, Lingenhöhl K, Spooren W, Gentsch C, Vassout A, Pilc A, Gasparini F. Kuhn R, et al. Among authors: spooren w. Amino Acids. 2002;23(1-3):207-11. doi: 10.1007/s00726-001-0130-6. Amino Acids. 2002. PMID: 12373539 Review.

2

mGlu5 receptor antagonists: a novel class of anxiolytics?

Spooren W, Gasparini F. Spooren W, et al. Drug News Perspect. 2004 May;17(4):251-7. doi: 10.1358/dnp.2004.17.4.829052. Drug News Perspect. 2004. PMID: 15334174 Review.

3

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, Gasparini F, Spooren W, Stoehr N, Pagano A, Flor PJ, Vranesic I, Lingenhoehl K, Johnson EC, Varney M, Urban L, Kuhn R. Walker K, et al. Among authors: spooren w. Neuropharmacology. 2001;40(1):1-9. doi: 10.1016/s0028-3908(00)00113-1. Neuropharmacology. 2001. PMID: 11077065

4

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice.

Spooren WP, Gasparini F, van der Putten H, Koller M, Nakanishi S, Kuhn R. Spooren WP, et al. Eur J Pharmacol. 2000 May 26;397(1):R1-2. doi: 10.1016/s0014-2999(00)00269-7. Eur J Pharmacol. 2000. PMID: 10844118

5

Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats.

Spooren WP, Gasparini F, Bergmann R, Kuhn R. Spooren WP, et al. Eur J Pharmacol. 2000 Oct 20;406(3):403-10. doi: 10.1016/s0014-2999(00)00697-x. Eur J Pharmacol. 2000. PMID: 11040347

6

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

Spooren WP, Vassout A, Neijt HC, Kuhn R, Gasparini F, Roux S, Porsolt RD, Gentsch C. Spooren WP, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1267-75. J Pharmacol Exp Ther. 2000. PMID: 11082464

7

Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders.

Spooren WP, Gasparini F, Salt TE, Kuhn R. Spooren WP, et al. Trends Pharmacol Sci. 2001 Jul;22(7):331-7. doi: 10.1016/s0165-6147(00)01694-1. Trends Pharmacol Sci. 2001. PMID: 11431019 Review.

8

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

Spooren WP, Schoeffter P, Gasparini F, Kuhn R, Gentsch C. Spooren WP, et al. Eur J Pharmacol. 2002 Jan 25;435(2-3):161-70. doi: 10.1016/s0014-2999(01)01562-x. Eur J Pharmacol. 2002. PMID: 11821022

9

mGluR5 antagonists: discovery, characterization and drug development.

Gasparini F, Bilbe G, Gomez-Mancilla B, Spooren W. Gasparini F, et al. Among authors: spooren w. Curr Opin Drug Discov Devel. 2008 Sep;11(5):655-65. Curr Opin Drug Discov Devel. 2008. PMID: 18729017 Review.

10

Metabotropic glutamate receptors: their therapeutic potential in anxiety.

Spooren W, Lesage A, Lavreysen H, Gasparini F, Steckler T. Spooren W, et al. Curr Top Behav Neurosci. 2010;2:391-413. doi: 10.1007/7854_2010_36. Curr Top Behav Neurosci. 2010. PMID: 21309118 Review.

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