Lemoine H - Search Results

1

Molecular modeling and QSAR studies on K(ATP) channel openers of the benzopyran type.

Uhrig U, Höltje HD, Mannhold R, Weber H, Lemoine H. Uhrig U, et al. Among authors: lemoine h. J Mol Graph Model. 2002 Aug;21(1):37-45. doi: 10.1016/s1093-3263(02)00107-9. J Mol Graph Model. 2002. PMID: 12413029

2

Relaxant activity in rat aorta and trachea, conversion to a muscarinic receptor antagonist and structure-activity relationships of new K(ATP) activating 6-varied benzopyrans.

Lemoine H, Weber H, Derix A, Uhrig U, Höltje HD, Mannhold R. Lemoine H, et al. Eur J Pharmacol. 1999 Jul 28;378(1):85-97. doi: 10.1016/s0014-2999(99)00453-7. Eur J Pharmacol. 1999. PMID: 10478568

3

6-Sulfonylchromenes as highly potent K(ATP)-channel openers.

Salamon E, Mannhold R, Weber H, Lemoine H, Frank W. Salamon E, et al. Among authors: lemoine h. J Med Chem. 2002 Feb 28;45(5):1086-97. doi: 10.1021/jm010999g. J Med Chem. 2002. PMID: 11855989

4

KATP channel openers of the benzopyran type reach their binding site via the cytosol.

Stephan D, Salamon E, Weber H, Russ U, Lemoine H, Quast U. Stephan D, et al. Among authors: lemoine h. Br J Pharmacol. 2006 Sep;149(2):199-205. doi: 10.1038/sj.bjp.0706858. Epub 2006 Aug 14. Br J Pharmacol. 2006. PMID: 16921394 Free PMC article.

5

6-Substituted benzopyrans as potassium channel activators: synthesis, vasodilator properties, and multivariate analysis.

Mannhold R, Cruciani G, Weber H, Lemoine H, Derix A, Weichel C, Clementi M. Mannhold R, et al. Among authors: lemoine h. J Med Chem. 1999 Mar 25;42(6):981-91. doi: 10.1021/jm981047m. J Med Chem. 1999. PMID: 10090781

6

Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type K(ATP)-channel openers.

Carosati E, Lemoine H, Spogli R, Grittner D, Mannhold R, Tabarrini O, Sabatini S, Cecchetti V. Carosati E, et al. Among authors: lemoine h. Bioorg Med Chem. 2005 Oct 1;13(19):5581-91. doi: 10.1016/j.bmc.2005.06.010. Bioorg Med Chem. 2005. PMID: 16002299

7

Structural dependence of the allosteric interaction of semi-rigid verapamil analogues with dihydropyridine-binding in kitten heart.

Voigt W, Romanelli MN, Lemoine H, Mannhold R, Dei S, Teodori E, Gualtieri F. Voigt W, et al. Among authors: lemoine h. Eur J Pharmacol. 1995 Nov 30;291(3):255-64. doi: 10.1016/0922-4106(95)90065-9. Eur J Pharmacol. 1995. PMID: 8719409

8

Synthesis of benzofuran, benzothiophene, and benzothiazole-based thioamides and their evaluation as K(ATP) channel openers.

Fischer A, Schmidt C, Lachenicht S, Grittner D, Winkler M, Wrobel T, Rood A, Lemoine H, Frank W, Braun M. Fischer A, et al. Among authors: lemoine h. ChemMedChem. 2010 Oct 4;5(10):1749-59. doi: 10.1002/cmdc.201000297. ChemMedChem. 2010. PMID: 20845362

9

Synthesis of modified 4H-1,2,4-benzothiadiazine-1,1-dioxides and determination of their affinity and selectivity for different types of K(ATP) channels.

Lachenicht S, Fischer A, Schmidt C, Winkler M, Rood A, Lemoine H, Braun M. Lachenicht S, et al. Among authors: lemoine h. ChemMedChem. 2009 Nov;4(11):1850-8. doi: 10.1002/cmdc.200900261. ChemMedChem. 2009. PMID: 19774590

10

Verapamil analogues with restricted molecular flexibility: synthesis and pharmacological evaluation of the four isomers of alpha-[1-[3-[N-[1- [2-(3,4-dimethoxyphenyl)ethyl]]-N-methylamino]cyclohexyl]]-alpha- isopropyl-3,4-dimethoxybenzene-acetonitrile.

Dei S, Romanelli MN, Scapecchi S, Teodori E, Gualtieri F, Chiarini A, Voigt W, Lemoine H. Dei S, et al. Among authors: lemoine h. J Med Chem. 1993 Feb 19;36(4):439-45. doi: 10.1021/jm00056a003. J Med Chem. 1993. PMID: 8474099

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