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Page 1
Highly potent inhibitors of TNF-alpha production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer.
Matsui T, Kondo T, Nishita Y, Itadani S, Tsuruta H, Fujita S, Omawari N, Sakai M, Nakazawa S, Ogata A, Mori H, Kamoshima W, Terai K, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: itadani s. Bioorg Med Chem. 2002 Dec;10(12):3787-805. doi: 10.1016/s0968-0896(02)00380-2. Bioorg Med Chem. 2002. PMID: 12413833
Design and synthesis of novel metalloproteinase inhibitors.
Nakatani S, Ikura M, Yamamoto S, Nishita Y, Itadani S, Habashita H, Sugiura T, Ogawa K, Ohno H, Takahashi K, Nakai H, Toda M. Nakatani S, et al. Among authors: itadani s. Bioorg Med Chem. 2006 Aug 1;14(15):5402-22. doi: 10.1016/j.bmc.2006.03.032. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621578
Design and synthesis of an orally active matrix metalloproteinase inhibitor.
Yamamoto S, Nakatani S, Ikura M, Sugiura T, Nishita Y, Itadani S, Ogawa K, Ohno H, Takahashi K, Nakai H, Toda M. Yamamoto S, et al. Among authors: itadani s. Bioorg Med Chem. 2006 Sep 15;14(18):6383-403. doi: 10.1016/j.bmc.2006.05.040. Epub 2006 Jun 9. Bioorg Med Chem. 2006. PMID: 16765051
Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist.
Itadani S, Takahashi S, Ima M, Sekiguchi T, Fujita M, Nakayama Y, Takeuchi J. Itadani S, et al. ACS Med Chem Lett. 2014 Oct 6;5(11):1230-4. doi: 10.1021/ml500298y. eCollection 2014 Nov 13. ACS Med Chem Lett. 2014. PMID: 25408836 Free PMC article.
Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma.
Itadani S, Yashiro K, Aratani Y, Sekiguchi T, Kinoshita A, Moriguchi H, Ohta N, Takahashi S, Ishida A, Tajima Y, Hisaichi K, Ima M, Ueda J, Egashira H, Sekioka T, Kadode M, Yonetomi Y, Nakao T, Inoue A, Nomura H, Kitamine T, Fujita M, Nabe T, Yamaura Y, Matsumura N, Imagawa A, Nakayama Y, Takeuchi J, Ohmoto K. Itadani S, et al. J Med Chem. 2015 Aug 13;58(15):6093-113. doi: 10.1021/acs.jmedchem.5b00741. Epub 2015 Jul 22. J Med Chem. 2015. PMID: 26200813