Ohno H - Search Results

1

Highly potent inhibitors of TNF-alpha production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer.

Matsui T, Kondo T, Nishita Y, Itadani S, Tsuruta H, Fujita S, Omawari N, Sakai M, Nakazawa S, Ogata A, Mori H, Kamoshima W, Terai K, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: ohno h. Bioorg Med Chem. 2002 Dec;10(12):3787-805. doi: 10.1016/s0968-0896(02)00380-2. Bioorg Med Chem. 2002. PMID: 12413833

2

Highly potent inhibitors of TNF-alpha production. Part 1: Discovery of chemical leads.

Matsui T, Kondo T, Nishita Y, Itadani S, Nakatani S, Omawari N, Sakai M, Nakazawa S, Ogata A, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: ohno h. Bioorg Med Chem Lett. 2002 Mar 25;12(6):903-5. doi: 10.1016/s0960-894x(02)00036-7. Bioorg Med Chem Lett. 2002. PMID: 11958990

3

Highly potent inhibitors of TNF-alpha production. Part 2: identification of drug candidates.

Matsui T, Kondo T, Nishita Y, Itadani S, Tsuruta H, Fujita S, Omawari N, Sakai M, Nakazawa S, Ogata A, Mori H, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: ohno h. Bioorg Med Chem Lett. 2002 Mar 25;12(6):907-10. doi: 10.1016/s0960-894x(02)00037-9. Bioorg Med Chem Lett. 2002. PMID: 11958991

4

Highly potent inhibitors of TNF-alpha production. Part I: discovery of new chemical leads and their structure-activity relationships.

Matsui T, Kondo T, Nishita Y, Itadani S, Nakatani S, Omawari N, Sakai M, Nakazawa S, Ogata A, Mori H, Terai K, Kamoshima W, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: ohno h. Bioorg Med Chem. 2002 Dec;10(12):3757-86. doi: 10.1016/s0968-0896(02)00381-4. Bioorg Med Chem. 2002. PMID: 12413832

5

Discovery of novel phosphonic acid derivatives as new chemical leads for inhibitors of TNF-alpha production.

Matsui T, Takahashi S, Matsunaga N, Nakamura K, Omawari N, Sakai M, Kamoshima W, Terai K, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: ohno h. Bioorg Med Chem. 2002 Dec;10(12):3807-15. doi: 10.1016/s0968-0896(02)00343-7. Bioorg Med Chem. 2002. PMID: 12413834

6

Synthesis, further biological evaluation and pharmacodynamics of newly discovered inhibitors of TNF-alpha production.

Matsui T, Kondo T, Nakatani S, Omawari N, Sakai M, Mori H, Ogata A, Kato J, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: ohno h. Bioorg Med Chem. 2003 Sep 1;11(18):3937-43. doi: 10.1016/s0968-0896(03)00409-7. Bioorg Med Chem. 2003. PMID: 12927854

7

Discovery of a new chemical lead for a matrix metalloproteinase inhibitor.

Ikura M, Nakatani S, Yamamoto S, Habashita H, Sugiura T, Takahashi K, Ogawa K, Ohno H, Nakai H, Toda M. Ikura M, et al. Among authors: ohno h. Bioorg Med Chem. 2006 Jun 15;14(12):4241-52. doi: 10.1016/j.bmc.2006.01.059. Epub 2006 Feb 14. Bioorg Med Chem. 2006. PMID: 16481176

8

Design and synthesis of novel metalloproteinase inhibitors.

Nakatani S, Ikura M, Yamamoto S, Nishita Y, Itadani S, Habashita H, Sugiura T, Ogawa K, Ohno H, Takahashi K, Nakai H, Toda M. Nakatani S, et al. Among authors: ohno h. Bioorg Med Chem. 2006 Aug 1;14(15):5402-22. doi: 10.1016/j.bmc.2006.03.032. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621578

9

Design and synthesis of an orally active matrix metalloproteinase inhibitor.

Yamamoto S, Nakatani S, Ikura M, Sugiura T, Nishita Y, Itadani S, Ogawa K, Ohno H, Takahashi K, Nakai H, Toda M. Yamamoto S, et al. Among authors: ohno h. Bioorg Med Chem. 2006 Sep 15;14(18):6383-403. doi: 10.1016/j.bmc.2006.05.040. Epub 2006 Jun 9. Bioorg Med Chem. 2006. PMID: 16765051

10

Novel matrix metalloproteinase inhibitors: generation of lead compounds by the in silico fragment-based approach.

Takahashi K, Ikura M, Habashita H, Nishizaki M, Sugiura T, Yamamoto S, Nakatani S, Ogawa K, Ohno H, Nakai H, Toda M. Takahashi K, et al. Among authors: ohno h. Bioorg Med Chem. 2005 Jul 15;13(14):4527-43. doi: 10.1016/j.bmc.2005.04.051. Bioorg Med Chem. 2005. PMID: 15908222

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