Dafforn TR - Search Results

1

Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila.

Robertson AS, Belorgey D, Lilley KS, Lomas DA, Gubb D, Dafforn TR. Robertson AS, et al. Among authors: dafforn tr. J Biol Chem. 2003 Feb 21;278(8):6175-80. doi: 10.1074/jbc.M209277200. Epub 2002 Oct 31. J Biol Chem. 2003. PMID: 12414799 Free article.

2

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.

Mahadeva R, Dafforn TR, Carrell RW, Lomas DA. Mahadeva R, et al. Among authors: dafforn tr. J Biol Chem. 2002 Mar 1;277(9):6771-4. doi: 10.1074/jbc.C100722200. Epub 2001 Dec 28. J Biol Chem. 2002. PMID: 11773044 Free article.

3

Drosophila necrotic mutations mirror disease-associated variants of human serpins.

Green C, Brown G, Dafforn TR, Reichhart JM, Morley T, Lomas DA, Gubb D. Green C, et al. Among authors: dafforn tr. Development. 2003 Apr;130(7):1473-8. doi: 10.1242/dev.00350. Development. 2003. PMID: 12588861 Free article.

4

Inhibitory activity of the Drosophila melanogaster serpin Necrotic is dependent on lysine residues in the D-helix.

Robertson AS, Belorgey D, Gubb D, Dafforn TR, Lomas DA. Robertson AS, et al. Among authors: dafforn tr. J Biol Chem. 2006 Sep 8;281(36):26437-43. doi: 10.1074/jbc.M606085200. Epub 2006 Jul 11. J Biol Chem. 2006. PMID: 16835244 Free article.

5

Pathogenic alpha 1-antitrypsin polymers are formed by reactive loop-beta-sheet A linkage.

Sivasothy P, Dafforn TR, Gettins PG, Lomas DA. Sivasothy P, et al. Among authors: dafforn tr. J Biol Chem. 2000 Oct 27;275(43):33663-8. doi: 10.1074/jbc.M004054200. J Biol Chem. 2000. PMID: 10924508 Free article.

6

The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.

Green C, Levashina E, McKimmie C, Dafforn T, Reichhart JM, Gubb D. Green C, et al. Genetics. 2000 Nov;156(3):1117-27. doi: 10.1093/genetics/156.3.1117. Genetics. 2000. PMID: 11063688 Free PMC article.

7

Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease.

Parfrey H, Mahadeva R, Ravenhill NA, Zhou A, Dafforn TR, Foreman RC, Lomas DA. Parfrey H, et al. Among authors: dafforn tr. J Biol Chem. 2003 Aug 29;278(35):33060-6. doi: 10.1074/jbc.M302646200. Epub 2003 Jun 13. J Biol Chem. 2003. PMID: 12807889 Free article.

8

Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic.

Pelte N, Robertson AS, Zou Z, Belorgey D, Dafforn TR, Jiang H, Lomas D, Reichhart JM, Gubb D. Pelte N, et al. Among authors: dafforn tr. Insect Biochem Mol Biol. 2006 Jan;36(1):37-46. doi: 10.1016/j.ibmb.2005.10.004. Epub 2005 Nov 8. Insect Biochem Mol Biol. 2006. PMID: 16360948 Free PMC article.

9

Polymerization of plasminogen activator inhibitor-1.

Zhou A, Faint R, Charlton P, Dafforn TR, Carrell RW, Lomas DA. Zhou A, et al. Among authors: dafforn tr. J Biol Chem. 2001 Mar 23;276(12):9115-22. doi: 10.1074/jbc.M010631200. Epub 2000 Dec 1. J Biol Chem. 2001. PMID: 11102455 Free article.

10

A kinetic mechanism for the polymerization of alpha1-antitrypsin.

Dafforn TR, Mahadeva R, Elliott PR, Sivasothy P, Lomas DA. Dafforn TR, et al. J Biol Chem. 1999 Apr 2;274(14):9548-55. doi: 10.1074/jbc.274.14.9548. J Biol Chem. 1999. PMID: 10092640 Free article.

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