Steeghs L - Search Results

1

Neisseria meningitidis can induce pro-inflammatory cytokine production via pathways independent from CD14 and toll-like receptor 4.

Sprong T, van der Ley P, Steeghs L, Taw WJ, Verver-Janssen TJ, Netea MG, van der Meer JW, van Deuren M. Sprong T, et al. Among authors: steeghs l. Eur Cytokine Netw. 2002 Oct-Dec;13(4):411-7. Eur Cytokine Netw. 2002. PMID: 12517725 Free article.

2

Lessons from an LPS-deficient Neisseria meningitidis mutant.

van der Ley P, Steeghs L. van der Ley P, et al. Among authors: steeghs l. J Endotoxin Res. 2003;9(2):124-8. doi: 10.1179/096805103125001522. J Endotoxin Res. 2003. PMID: 12803887

3

Mannose binding lectin enhances IL-1beta and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis.

Sprong T, Jack DL, Klein NJ, Turner MW, van der Ley P, Steeghs L, Jacobs L, van der Meer JW, van Deuren M. Sprong T, et al. Among authors: steeghs l. Cytokine. 2004 Oct 21;28(2):59-66. doi: 10.1016/j.cyto.2004.06.007. Cytokine. 2004. PMID: 15381182

4

Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response.

Sprong T, Stikkelbroeck N, van der Ley P, Steeghs L, van Alphen L, Klein N, Netea MG, van der Meer JW, van Deuren M. Sprong T, et al. Among authors: steeghs l. J Leukoc Biol. 2001 Aug;70(2):283-8. J Leukoc Biol. 2001. PMID: 11493621

5

Teasing apart structural determinants of 'toxicity' and 'adjuvanticity': implications for meningococcal vaccine development.

Steeghs L, Tommassen J, Leusen JH, van de Winkel JG, van der Ley P. Steeghs L, et al. J Endotoxin Res. 2004;10(2):113-9. doi: 10.1179/096805104225004059. J Endotoxin Res. 2004. PMID: 15120002

6

Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis.

Steeghs L, Keestra AM, van Mourik A, Uronen-Hansson H, van der Ley P, Callard R, Klein N, van Putten JP. Steeghs L, et al. Infect Immun. 2008 Aug;76(8):3801-7. doi: 10.1128/IAI.00005-08. Epub 2008 May 19. Infect Immun. 2008. PMID: 18490457 Free PMC article.

7

Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity.

Steeghs L, Berns M, ten Hove J, de Jong A, Roholl P, van Alphen L, Tommassen J, van der Ley P. Steeghs L, et al. Cell Microbiol. 2002 Sep;4(9):599-611. doi: 10.1046/j.1462-5822.2002.00214.x. Cell Microbiol. 2002. PMID: 12390352

8

TLR4-dependent adjuvant activity of Neisseria meningitidis lipid A.

Zughaier S, Steeghs L, van der Ley P, Stephens DS. Zughaier S, et al. Among authors: steeghs l. Vaccine. 2007 May 30;25(22):4401-9. doi: 10.1016/j.vaccine.2007.03.029. Epub 2007 Apr 2. Vaccine. 2007. PMID: 17466419 Free PMC article.

9

A critical contribution of both CD28 and ICOS in the adjuvant activity of Neisseria meningitidis H44/76 LPS and lpxL1 LPS.

van Berkel ME, Schrijver EH, van Mourik A, Tesselaar K, van der Ley P, Steeghs L, Oosterwegel MA. van Berkel ME, et al. Among authors: steeghs l. Vaccine. 2007 Jun 11;25(24):4681-8. doi: 10.1016/j.vaccine.2007.04.016. Epub 2007 Apr 25. Vaccine. 2007. PMID: 17499399

10

A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via toll-like receptor (TLR) 2 but not via TLR4/MD2.

Pridmore AC, Wyllie DH, Abdillahi F, Steeghs L, van der Ley P, Dower SK, Read RC. Pridmore AC, et al. Among authors: steeghs l. J Infect Dis. 2001 Jan 1;183(1):89-96. doi: 10.1086/317647. Epub 2000 Nov 10. J Infect Dis. 2001. PMID: 11076707

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