Pearl LH - Search Results

1

Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors.

Piper PW, Panaretou B, Millson SH, Truman A, Mollapour M, Pearl LH, Prodromou C. Piper PW, et al. Among authors: pearl lh. Gene. 2003 Jan 2;302(1-2):165-70. doi: 10.1016/s0378-1119(02)01102-2. Gene. 2003. PMID: 12527207

2

Recursive PCR: a novel technique for total gene synthesis.

Prodromou C, Pearl LH. Prodromou C, et al. Among authors: pearl lh. Protein Eng. 1992 Dec;5(8):827-9. doi: 10.1093/protein/5.8.827. Protein Eng. 1992. PMID: 1287665 No abstract available.

3

Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect.

Wheeler VC, Prodromou C, Pearl LH, Williamson R, Coutelle C. Wheeler VC, et al. Among authors: pearl lh. Gene. 1996 Mar 9;169(2):251-5. doi: 10.1016/0378-1119(95)00812-8. Gene. 1996. PMID: 8647457

4

Expression and crystallization of the yeast Hsp82 chaperone, and preliminary X-ray diffraction studies of the amino-terminal domain.

Prodromou C, Piper PW, Pearl LH. Prodromou C, et al. Among authors: pearl lh. Proteins. 1996 Aug;25(4):517-22. doi: 10.1002/prot.13. Proteins. 1996. PMID: 8865348

5

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.

Prodromou C, Roe SM, Piper PW, Pearl LH. Prodromou C, et al. Among authors: pearl lh. Nat Struct Biol. 1997 Jun;4(6):477-82. doi: 10.1038/nsb0697-477. Nat Struct Biol. 1997. PMID: 9187656

6

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.

Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Prodromou C, et al. Among authors: pearl lh. Cell. 1997 Jul 11;90(1):65-75. doi: 10.1016/s0092-8674(00)80314-1. Cell. 1997. PMID: 9230303 Free article.

7

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo.

Panaretou B, Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Panaretou B, et al. Among authors: pearl lh. EMBO J. 1998 Aug 17;17(16):4829-36. doi: 10.1093/emboj/17.16.4829. EMBO J. 1998. PMID: 9707442 Free PMC article.

8

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Roe SM, et al. Among authors: pearl lh. J Med Chem. 1999 Jan 28;42(2):260-6. doi: 10.1021/jm980403y. J Med Chem. 1999. PMID: 9925731

9

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones.

Prodromou C, Siligardi G, O'Brien R, Woolfson DN, Regan L, Panaretou B, Ladbury JE, Piper PW, Pearl LH. Prodromou C, et al. Among authors: pearl lh. EMBO J. 1999 Feb 1;18(3):754-62. doi: 10.1093/emboj/18.3.754. EMBO J. 1999. PMID: 9927435 Free PMC article.

10

The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections.

Panaretou B, Sinclair K, Prodromou C, Johal J, Pearl L, Piper PW. Panaretou B, et al. Microbiology (Reading). 1999 Dec;145 ( Pt 12):3455-3463. doi: 10.1099/00221287-145-12-3455. Microbiology (Reading). 1999. PMID: 10627043 Free article.

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