Piper PW - Search Results

1

Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors.

Piper PW, Panaretou B, Millson SH, Truman A, Mollapour M, Pearl LH, Prodromou C. Piper PW, et al. Gene. 2003 Jan 2;302(1-2):165-70. doi: 10.1016/s0378-1119(02)01102-2. Gene. 2003. PMID: 12527207

2

Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast.

Piper PW, Millson SH, Mollapour M, Panaretou B, Siligardi G, Pearl LH, Prodromou C. Piper PW, et al. Eur J Biochem. 2003 Dec;270(23):4689-95. doi: 10.1046/j.1432-1033.2003.03866.x. Eur J Biochem. 2003. PMID: 14622256 Free article.

3

In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity.

Truman AW, Millson SH, Nuttall JM, Mollapour M, Prodromou C, Piper PW. Truman AW, et al. Among authors: piper pw. Eukaryot Cell. 2007 Apr;6(4):744-52. doi: 10.1128/EC.00009-07. Epub 2007 Feb 9. Eukaryot Cell. 2007. PMID: 17293484 Free PMC article.

4

Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.

Millson SH, Truman AW, Rácz A, Hu B, Panaretou B, Nuttall J, Mollapour M, Söti C, Piper PW. Millson SH, et al. Among authors: piper pw. FEBS J. 2007 Sep;274(17):4453-63. doi: 10.1111/j.1742-4658.2007.05974.x. Epub 2007 Aug 6. FEBS J. 2007. PMID: 17681020 Free article.

5

A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta.

Millson SH, Prodromou C, Piper PW. Millson SH, et al. Among authors: piper pw. Biochem Pharmacol. 2010 Jun 1;79(11):1581-8. doi: 10.1016/j.bcp.2010.01.031. Epub 2010 Feb 4. Biochem Pharmacol. 2010. PMID: 20138026

6

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics.

Piper PW, Millson SH. Piper PW, et al. Open Biol. 2012 Dec 12;2(12):120138. doi: 10.1098/rsob.120138. Open Biol. 2012. PMID: 23271830 Free PMC article. Review.

7

The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections.

Panaretou B, Sinclair K, Prodromou C, Johal J, Pearl L, Piper PW. Panaretou B, et al. Among authors: piper pw. Microbiology (Reading). 1999 Dec;145 ( Pt 12):3455-3463. doi: 10.1099/00221287-145-12-3455. Microbiology (Reading). 1999. PMID: 10627043 Free article.

8

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo.

Panaretou B, Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Panaretou B, et al. Among authors: piper pw. EMBO J. 1998 Aug 17;17(16):4829-36. doi: 10.1093/emboj/17.16.4829. EMBO J. 1998. PMID: 9707442 Free PMC article.

9

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Roe SM, et al. Among authors: piper pw. J Med Chem. 1999 Jan 28;42(2):260-6. doi: 10.1021/jm980403y. J Med Chem. 1999. PMID: 9925731

10

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.

Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Prodromou C, et al. Among authors: piper pw. Cell. 1997 Jul 11;90(1):65-75. doi: 10.1016/s0092-8674(00)80314-1. Cell. 1997. PMID: 9230303 Free article.

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