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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD. Baillie GS, et al. Among authors: houslay md. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):940-5. doi: 10.1073/pnas.262787199. Epub 2003 Jan 27. Proc Natl Acad Sci U S A. 2003. Retraction in: Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2205198119. doi: 10.1073/pnas.2205198119 PMID: 12552097 Free PMC article. Retracted.
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
Huston E, Pooley L, Julien P, Scotland G, McPhee I, Sullivan M, Bolger G, Houslay MD. Huston E, et al. Among authors: houslay md. J Biol Chem. 1996 Dec 6;271(49):31334-44. doi: 10.1074/jbc.271.49.31334. J Biol Chem. 1996. PMID: 8940140 Free article.
Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant.
Erdogan S, Houslay MD. Erdogan S, et al. Among authors: houslay md. Biochem J. 1997 Jan 1;321 ( Pt 1)(Pt 1):165-75. doi: 10.1042/bj3210165. Biochem J. 1997. PMID: 9003416 Free PMC article.
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Houslay MD, Scotland G, Erdogan S, Huston E, Mackenzie S, McCallum JF, McPhee I, Pooley L, Rena G, Ross A, Beard M, Peder A, Begg F, Wilkinson I, Yarwood S, Ackerman C, Houslay ES, Hoffman R, Engels P, Sullivan M, Bolger G. Houslay MD, et al. Among authors: houslay es. Biochem Soc Trans. 1997 May;25(2):374-81. doi: 10.1042/bst0250374. Biochem Soc Trans. 1997. PMID: 9191121 Review. No abstract available.
413 results