Cihlar T - Search Results

1

Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells.

Birkus G, Gibbs CS, Cihlar T. Birkus G, et al. Among authors: cihlar t. J Viral Hepat. 2003 Jan;10(1):50-4. doi: 10.1046/j.1365-2893.2003.00399.x. J Viral Hepat. 2003. PMID: 12558912

2

A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture.

Cihlar T, Fuller MD, Mulato AS, Cherrington JM. Cihlar T, et al. Virology. 1998 Sep 1;248(2):382-93. doi: 10.1006/viro.1998.9299. Virology. 1998. PMID: 9721246 Free article.

3

The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.

Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH. Cihlar T, et al. Mol Pharmacol. 1999 Sep;56(3):570-80. doi: 10.1124/mol.56.3.570. Mol Pharmacol. 1999. PMID: 10462545

4

Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.

Ho ES, Lin DC, Mendel DB, Cihlar T. Ho ES, et al. Among authors: cihlar t. J Am Soc Nephrol. 2000 Mar;11(3):383-393. doi: 10.1681/ASN.V113383. J Am Soc Nephrol. 2000. PMID: 10703662

5

Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.

Mulato AS, Ho ES, Cihlar T. Mulato AS, et al. Among authors: cihlar t. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. J Pharmacol Exp Ther. 2000. PMID: 10991954

6

Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors.

Birkus G, Hitchcock MJ, Cihlar T. Birkus G, et al. Among authors: cihlar t. Antimicrob Agents Chemother. 2002 Mar;46(3):716-23. doi: 10.1128/AAC.46.3.716-723.2002. Antimicrob Agents Chemother. 2002. PMID: 11850253 Free PMC article.

7

Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.

Cihlar T, Birkus G, Greenwalt DE, Hitchcock MJ. Cihlar T, et al. Antiviral Res. 2002 Apr;54(1):37-45. doi: 10.1016/s0166-3542(01)00210-8. Antiviral Res. 2002. PMID: 11888656

8

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

Birkus G, Wang R, Liu X, Kutty N, MacArthur H, Cihlar T, Gibbs C, Swaminathan S, Lee W, McDermott M. Birkus G, et al. Among authors: cihlar t. Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. doi: 10.1128/AAC.00968-06. Epub 2006 Dec 4. Antimicrob Agents Chemother. 2007. PMID: 17145787 Free PMC article.

9

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

Cihlar T, Ray AS, Boojamra CG, Zhang L, Hui H, Laflamme G, Vela JE, Grant D, Chen J, Myrick F, White KL, Gao Y, Lin KY, Douglas JL, Parkin NT, Carey A, Pakdaman R, Mackman RL. Cihlar T, et al. Antimicrob Agents Chemother. 2008 Feb;52(2):655-65. doi: 10.1128/AAC.01215-07. Epub 2007 Dec 3. Antimicrob Agents Chemother. 2008. PMID: 18056282 Free PMC article.

Stray, K.-Y. Lin, Y. Gao, R. L. Mackman, and T. Cihlar, Antimicrob. Agents Chemother. 52:648-654, 2008). GS-9148 diphosphate acts as a competitive inhibitor of RT with respect to dATP (K(i) = 0.8 muM) and exhibits low inhibitory potency against host polymerases incl …

Stray, K.-Y. Lin, Y. Gao, R. L. Mackman, and T. Cihlar, Antimicrob. Agents Chemother. 52:648-654, 2008). GS-9148 diphosphate a …

10

Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.

Boojamra CG, Mackman RL, Markevitch DY, Prasad V, Ray AS, Douglas J, Grant D, Kim CU, Cihlar T. Boojamra CG, et al. Among authors: cihlar t. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1120-3. doi: 10.1016/j.bmcl.2007.11.125. Epub 2007 Dec 5. Bioorg Med Chem Lett. 2008. PMID: 18164198

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